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Hoxa10 Gene Detail
Summary
  • Symbol
    Hoxa10
  • Name
    homeobox A10
  • Synonyms
    Hox-1.8, Hoxa-10
  • Feature Type
    protein coding gene
  • IDs
    MGI:96171
    NCBI Gene: 15395
  • Member of
    Hoxa cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:52208177-52217658 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.40 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    162 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96171
 protein coding gene Chr6:52208177-52217834 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030748
 protein coding gene Chr6:51472368-51482023 (-)
A/J MGP_AJ_G0030717
 protein coding gene Chr6:49067029-49076682 (-)
AKR/J MGP_AKRJ_G0030644
 protein coding gene Chr6:50773448-50783104 (-)
BALB/cJ MGP_BALBcJ_G0030729
 protein coding gene Chr6:49427677-49437326 (-)
C3H/HeJ MGP_C3HHeJ_G0030442
 protein coding gene Chr6:50782485-50792138 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031184
 protein coding gene Chr6:52608666-52618323 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028390
 protein coding gene Chr6:46714872-46724514 (-)
CAST/EiJ MGP_CASTEiJ_G0029845
 protein coding gene Chr6:50597432-50607072 (-)
CBA/J MGP_CBAJ_G0030416
 protein coding gene Chr6:54809684-54819337 (-)
DBA/2J MGP_DBA2J_G0030566
 protein coding gene Chr6:48989450-48999103 (-)
FVB/NJ MGP_FVBNJ_G0030518
 protein coding gene Chr6:48601028-48610681 (-)
LP/J MGP_LPJ_G0030651
 protein coding gene Chr6:51451057-51460712 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030552
 protein coding gene Chr6:57437483-57447139 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031214
 protein coding gene Chr6:50702120-50711776 (-)
PWK/PhJ MGP_PWKPhJ_G0029558
 protein coding gene Chr6:48613430-48623085 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029392
 protein coding gene Chr6:50037523-50047143 (-)
WSB/EiJ MGP_WSBEiJ_G0029922
 protein coding gene Chr6:50718283-50727939 (-)



Homology
more
  • Human Ortholog
    HOXA10, homeobox A10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXA10, homeobox A10
  • Synonyms
    HOX1, HOX1.8, HOX1H, PL
  • Links
    NCBI Gene ID: 3206
    neXtProt AC: NX_P31260
    UniProt: P31260

  • Chr Location
    7p15.2; chr7:27170605-27180261 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes are viable with homeotic transformation of vertebrae and lumbar spinal nerves, misshapen femurs and degeneration of knee articulation. Males show cryptorchidism and testes dysmorphology. Females have uterine defects affecting embryo viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1268
  • Tissues
    302
  • cDNA Data
    39
  • Literature Summary
    96
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15395 NCBI Gene Model | MGI Sequence Detail 9482 C57BL/6J ±  kb
    transcript NM_008263 RefSeq | MGI Sequence Detail 2574 ZRU/MplStud  
    polypeptide P31310 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 12
      cDNA 42
      Primer pair 10
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10824, MGD-MRK-10872
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 96
      Gene Ontology 8
      Phenotypes 40
    • Earliest
      J:621 Hunt P, et al., A distinct Hox code for the branchial region of the vertebrate head. Nature. 1991 Oct 31;353(6347):861-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory