About   Help   FAQ
Pou2f3 Gene Detail
Summary
  • Symbol
    Pou2f3
  • Name
    POU domain, class 2, transcription factor 3
  • Synonyms
    Epoc-1, Oct11, Oct-11a, Otf-11, Otf11, Skin, Skin-1a, Skn-1a, Skn-li
  • Feature Type
    protein coding gene
  • IDs
    MGI:102565
    NCBI Gene: 18988
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:43035222-43117052 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2296 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102565
 protein coding gene Chr9:43035222-43121666 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034682
 protein coding gene Chr9:41506326-41596631 (-)
A/J MGP_AJ_G0034662
 protein coding gene Chr9:40396710-40482750 (-)
AKR/J MGP_AKRJ_G0034588
 protein coding gene Chr9:41181031-41269471 (-)
BALB/cJ MGP_BALBcJ_G0034653
 protein coding gene Chr9:40122728-40209497 (-)
C3H/HeJ MGP_C3HHeJ_G0034364
 protein coding gene Chr9:41676069-41764078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035176
 protein coding gene Chr9:42766555-42857507 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032089
 protein coding gene Chr9:40004828-40091249 (-)
CAST/EiJ MGP_CASTEiJ_G0033687
 protein coding gene Chr9:41480329-41579729 (-)
CBA/J MGP_CBAJ_G0034337
 protein coding gene Chr9:44282810-44377372 (-)
DBA/2J MGP_DBA2J_G0034496
 protein coding gene Chr9:40309342-40395486 (-)
FVB/NJ MGP_FVBNJ_G0034436
 protein coding gene Chr9:39543615-39631239 (-)
LP/J MGP_LPJ_G0034577
 protein coding gene Chr9:41795671-41885313 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034480
 protein coding gene Chr9:46228821-46320120 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035195
 protein coding gene Chr9:41092069-41181168 (-)
PWK/PhJ MGP_PWKPhJ_G0033392
 protein coding gene Chr9:40154673-40245146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033228
 protein coding gene Chr9:41379166-41472920 (-)
WSB/EiJ MGP_WSBEiJ_G0033800
 protein coding gene Chr9:41138345-41231611 (-)



Homology
more
  • Human Ortholog
    POU2F3, POU class 2 homeobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU2F3, POU class 2 homeobox 3
  • Synonyms
    Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a
  • Links
    NCBI Gene ID: 25833
    neXtProt AC: NX_Q9UKI9
    UniProt: Q9UKI9

  • Chr Location
    11q23.3; chr11:120236638-120319945 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null mutation exhibit defective keratinocyte differentiation, however the skin and coat appear normal. Mice homozygous for another null mutation display loss of sweet, umami and bitter taste perception and expansion of sour taste receptor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    82
  • cDNA Data
    13
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18988 NCBI Gene Model | MGI Sequence Detail 81831 C57BL/6J ±  kb
    transcript NM_011139 RefSeq | MGI Sequence Detail 2522 ZRU/MplStud  
    polypeptide P31362 UniProt | EBI | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 3
      cDNA 13
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13061, MGD-MRK-13067, MGD-MRK-16488, MGD-MRK-19442, MGD-MRK-19446
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 16
      Gene Ontology 9
      Phenotypes 48
    • Earliest
      J:10430 Goldsborough A, et al., Cloning and sequencing of POU-boxes expressed in mouse testis. Nucleic Acids Res. 1990 Mar 25;18(6):1634
    • Latest
      J:352249 Li Y, et al., Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice. JCI Insight. 2024 Jan 23;9(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory