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S100a9 Gene Detail
Summary
  • Symbol
    S100a9
  • Name
    S100 calcium binding protein A9 (calgranulin B)
  • Synonyms
    60B8Ag, BEE22, Cagb, GAGB, L1Ag, MRP14, p14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338947
    NCBI Gene: 20202
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90599939-90603028 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.91 cM, cytoband F1-F2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338947
 protein coding gene Chr3:90599937-90603028 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027480
 protein coding gene Chr3:91036333-91039420 (-)
A/J MGP_AJ_G0027444
 protein coding gene Chr3:87990507-87993600 (-)
AKR/J MGP_AKRJ_G0027409
 protein coding gene Chr3:90157082-90160122 (-)
BALB/cJ MGP_BALBcJ_G0027453
 protein coding gene Chr3:87947511-87950891 (-)
C3H/HeJ MGP_C3HHeJ_G0027195
 protein coding gene Chr3:90320128-90323209 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027899
 protein coding gene Chr3:94435804-94438879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025252
 protein coding gene Chr3:83492741-83496080 (-)
CAST/EiJ MGP_CASTEiJ_G0026641
 protein coding gene Chr3:90722771-90727078 (-)
CBA/J MGP_CBAJ_G0027170
 protein coding gene Chr3:97637289-97640376 (-)
DBA/2J MGP_DBA2J_G0027307
 protein coding gene Chr3:87357588-87360657 (-)
FVB/NJ MGP_FVBNJ_G0027275
 protein coding gene Chr3:85685231-85688322 (-)
LP/J MGP_LPJ_G0027416
 protein coding gene Chr3:92095108-92098194 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027296
 protein coding gene Chr3:103892323-103895400 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027958
 protein coding gene Chr3:89907153-89910219 (-)
PWK/PhJ MGP_PWKPhJ_G0026375
 protein coding gene Chr3:87256365-87259447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026195
 protein coding gene Chr3:89099509-89102551 (-)
WSB/EiJ MGP_WSBEiJ_G0026723
 protein coding gene Chr3:90312499-90316775 (-)



Homology
more
  • Human Ortholog
    S100A9, S100 calcium binding protein A9
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S100A9, S100 calcium binding protein A9
  • Synonyms
    60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14, S100-A9
  • Links
    NCBI Gene ID: 6280
    neXtProt AC: NX_P06702
    UniProt: P06702

  • Chr Location
    1q21.3; chr1:153357854-153361023 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human S100A9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit abnormal immune physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    24
  • cDNA Data
    25
  • Literature Summary
    23
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056071 Ensembl Gene Model | MGI Sequence Detail 3090 C57BL/6J ±  kb
transcript ENSMUST00000117167 Ensembl | MGI Sequence Detail 519 Not Applicable  
polypeptide ENSMUSP00000112843 Ensembl | MGI Sequence Detail 113 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 2
    cDNA 25
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1726, MGI:2139998, MGI:88245
References
more
  • Summaries
    All 199
    Developmental Gene Expression 23
    Diseases 1
    Gene Ontology 17
    Phenotypes 85
  • Earliest
    J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
  • Latest
    J:351641 Wang G, et al., S100A9 aggravates early brain injury after subarachnoid hemorrhage via inducing neuroinflammation and inflammasome activation. iScience. 2024 Mar 15;27(3):109165
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory