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Slc2a3 Gene Detail
Summary
  • Symbol
    Slc2a3
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 3
  • Synonyms
    Glut-3, Glut3
  • Feature Type
    protein coding gene
  • IDs
    MGI:95757
    NCBI Gene: 20527
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122704768-122778599 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.82 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1743 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95757
 protein coding gene Chr6:122704768-122779149 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031232
 protein coding gene Chr6:125835648-125917166 (-)
A/J MGP_AJ_G0031201
 protein coding gene Chr6:121071373-121151367 (-)
AKR/J MGP_AKRJ_G0031131
 protein coding gene Chr6:124418737-124499070 (-)
BALB/cJ MGP_BALBcJ_G0031211
 protein coding gene Chr6:120782484-120859142 (-)
C3H/HeJ MGP_C3HHeJ_G0030930
 protein coding gene Chr6:124380615-124466261 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031670
 protein coding gene Chr6:129161581-129241958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028827
 protein coding gene Chr6:117676705-117730796 (-)
CAST/EiJ MGP_CASTEiJ_G0030319
 protein coding gene Chr6:124647416-124728363 (-)
CBA/J MGP_CBAJ_G0030893
 protein coding gene Chr6:134190977-134269502 (-)
DBA/2J MGP_DBA2J_G0031049
 protein coding gene Chr6:119999047-120077098 (-)
FVB/NJ MGP_FVBNJ_G0031002
 protein coding gene Chr6:118941078-119014119 (-)
LP/J MGP_LPJ_G0031130
 protein coding gene Chr6:126026493-126110837 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031037
 protein coding gene Chr6:138145766-138235401 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031700
 protein coding gene Chr6:124312697-124393221 (-)
PWK/PhJ MGP_PWKPhJ_G0030033
 protein coding gene Chr6:118843292-118897744 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029861
 protein coding gene Chr6:122451186-122536680 (-)
WSB/EiJ MGP_WSBEiJ_G0030401
 protein coding gene Chr6:124626035-124707021 (-)



Homology
more
  • Human Ortholog
    SLC2A14, solute carrier family 2 member 14
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC2A14, solute carrier family 2 member 14
  • Synonyms
    GLUT14, SLC2A3P3
  • Links
    NCBI Gene ID: 144195
    neXtProt AC: NX_Q8TDB8
    UniProt: Q8TDB8

  • Chr Location
    12p13.31
  • Human Ortholog
    SLC2A3, solute carrier family 2 member 3
  • Synonyms
    GLUT3
  • Links
    NCBI Gene ID: 6515
    neXtProt AC: NX_P11169
    UniProt: P11169

  • Chr Location
    12p13.31; chr12:7919230-8019007 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations cause embryonic lethality. Heterozygotes for a null allele show partial perinatal lethality and impaired placental transport. Heterozygotes for a gene trap allele show abnormal brain wave patterns, increased startle reflex, reduced prepulse inhibition and increased anxiety.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1047
  • Tissues
    164
  • cDNA Data
    27
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003153 Ensembl Gene Model | MGI Sequence Detail 73832 C57BL/6J ±  kb
    transcript ENSMUST00000032476 Ensembl | MGI Sequence Detail 3959 Not Applicable  
    polypeptide ENSMUSP00000032476 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000015065 solute carrier family 2, facilitated glucose transporter member 3
      (term hierarchy)
    • InterPro Domains
      IPR045263 Glucose transporter GLUT
      IPR002945 Glucose transporter, type 3 (GLUT3)
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    • GlyGen
      P32037 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 3
      cDNA 28
      Primer pair 11

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10157, MGD-MRK-10161, MGI:1353648, MGI:1889340, MGI:2141536, MGI:2141541, MGI:2141583
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 49
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:9395 Kayano T, et al., Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. J Biol Chem. 1988 Oct 25;263(30):15245-8
    • Latest
      J:342290 Yu DM, et al., GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing. J Clin Invest. 2023 Nov 1;133(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory