Ssb MGI Mouse Gene Detail - MGI:98423 - small RNA binding exonuclease protection factor La

Symbol

Ssb
Name

small RNA binding exonuclease protection factor La
Synonyms

autoantigen La, La protein, Sjogren syndrome antigen B, SS-B

Feature Type

protein coding gene
IDs

MGI:98423
NCBI Gene: 20823
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:69691963-69702185 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 40.95 cM
Mapping Data

2 experiments

SNPs within 2kb

260 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98423	protein coding gene	Chr2:69691906-69702190 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025807	protein coding gene	Chr2:69858271-69868550 (+)
A/J	MGP_AJ_G0025784	protein coding gene	Chr2:67165030-67175315 (+)
AKR/J	MGP_AKRJ_G0025753	protein coding gene	Chr2:68983330-68993615 (+)
BALB/cJ	MGP_BALBcJ_G0025779	protein coding gene	Chr2:67326131-67336415 (+)
C3H/HeJ	MGP_C3HHeJ_G0025539	protein coding gene	Chr2:69217533-69227816 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026226	protein coding gene	Chr2:71973096-71983384 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023629	protein coding gene	Chr2:64390722-64400918 (+)
CAST/EiJ	MGP_CASTEiJ_G0025003	protein coding gene	Chr2:69330455-69340733 (+)
CBA/J	MGP_CBAJ_G0025519	protein coding gene	Chr2:74628407-74640958 (+)
DBA/2J	MGP_DBA2J_G0025650	protein coding gene	Chr2:66798525-66808809 (+)
FVB/NJ	MGP_FVBNJ_G0025613	protein coding gene	Chr2:66178662-66188940 (+)
LP/J	MGP_LPJ_G0025739	protein coding gene	Chr2:69720139-69730423 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025642	protein coding gene	Chr2:76690692-76700977 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026283	protein coding gene	Chr2:69068382-69078666 (+)
PWK/PhJ	MGP_PWKPhJ_G0024744	protein coding gene	Chr2:66649383-66659755 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024551	protein coding gene	Chr2:69300097-69310361 (+)
WSB/EiJ	MGP_WSBEiJ_G0025071	protein coding gene	Chr2:69499290-69509567 (+)

Human Ortholog

SSB, small RNA binding exonuclease protection factor La

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSB, small RNA binding exonuclease protection factor La
Synonyms

La, LARP3, La/SSB
Links

HGNC:11316

NCBI Gene ID: 6741

neXtProt AC: NX_P05455

UniProt: P05455
Chr Location

2q31.1; chr2:169791933-169812064 (+) GRCh38

MGI Vertebrate Homology

Ssb stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: SSB
Gene Tree

Ssb

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Phenotype Summary

19 phenotypes from 3 alleles in 4 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

26
Targeted

5
Genomic Mutations

1 involving Ssb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die as embryos, possible before implantation.

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

41
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SSB

Xenbase ssb

ZFIN ssb

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All Sequences

83
RefSeq

27
UniProt

9
CCDS

CCDS16101.1

Ensembl

ENSMUSG00000068882 (Evidence)
NCBI Gene

20823

			Length	Strain/Species	Flank
genomic	20823	NCBI Gene Model \| MGI Sequence Detail	10223	C57BL/6J	± kb
transcript	NM_001421045	RefSeq \| MGI Sequence Detail	2952	ZRU/MplStud
polypeptide	P32067	UniProt \| EBI \| MGI Sequence Detail	415	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000015647 lupus La protein

(term hierarchy)
InterPro Domains

IPR045180 La domain containing protein

IPR014886 La protein, xRRM domain

IPR006630 La-type HTH domain

IPR002344 Lupus La protein

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P32067 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 20

Primer pair 2

Microarray probesets 6

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MGD-MRK-14607

Summaries

All 42

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 11
Earliest

J:4633 Topfer F, et al., Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies. J Immunol. 1993 Apr 1;150(7):3091-100
Latest

J:321251 Yang N, et al., Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. J Dent Res. 2022 Feb;101(2):226-234

TSS for Ssb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18173	Chr2:69691921-69691928 (+)	-38 bp
Tssr18174	Chr2:69691929-69691979 (+)	-9 bp
Tssr18175	Chr2:69691982-69691997 (+)	27 bp
Tssr18176	Chr2:69692519-69692522 (+)	558 bp
Tssr18177	Chr2:69697792-69697806 (+)	5,836 bp
Tssr18178	Chr2:69697834-69697872 (+)	5,890 bp
Tssr18179	Chr2:69700260-69700276 (+)	8,305 bp
Tssr18180	Chr2:69700723-69700737 (+)	8,767 bp
Tssr18181	Chr2:69700748-69700768 (+)	8,795 bp
Tssr18182	Chr2:69701015-69701056 (+)	9,073 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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