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Chrm4 Gene Detail
Summary
  • Symbol
    Chrm4
  • Name
    cholinergic receptor, muscarinic 4
  • Synonyms
    Chrm-4, muscarinic acetylcholine receptor 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88399
    NCBI Gene: 12672
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr2:91757594-91759033 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88399
 protein coding gene Chr2:91752531-91760180 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026158
 protein coding gene Chr2:93311094-93312533 (+)
A/J MGP_AJ_G0026119
 protein coding gene Chr2:89552396-89553835 (+)
AKR/J MGP_AKRJ_G0026100
 protein coding gene Chr2:92025060-92026499 (+)
BALB/cJ MGP_BALBcJ_G0026128
 protein coding gene Chr2:89738502-89739941 (+)
C3H/HeJ MGP_C3HHeJ_G0025879
 protein coding gene Chr2:92325359-92326798 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026579
 protein coding gene Chr2:96539438-96540877 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023970
 protein coding gene Chr2:86046366-86047805 (+)
CAST/EiJ MGP_CASTEiJ_G0025344
 protein coding gene Chr2:92866312-92867751 (+)
CBA/J MGP_CBAJ_G0025857
 protein coding gene Chr2:99878927-99880366 (+)
DBA/2J MGP_DBA2J_G0025993
 protein coding gene Chr2:89149134-89150573 (+)
FVB/NJ MGP_FVBNJ_G0025956
 protein coding gene Chr2:88246053-88247492 (+)
LP/J MGP_LPJ_G0026097
 protein coding gene Chr2:93507404-93508843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025982
 protein coding gene Chr2:102876179-102877618 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026633
 protein coding gene Chr2:92109018-92110457 (+)
PWK/PhJ MGP_PWKPhJ_G0025079
 protein coding gene Chr2:88885689-88887128 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024880
 protein coding gene Chr2:91672771-91674210 (+)
WSB/EiJ MGP_WSBEiJ_G0025411
 protein coding gene Chr2:92715209-92716648 (+)



Homology
more
  • Human Ortholog
    CHRM4, cholinergic receptor muscarinic 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRM4, cholinergic receptor muscarinic 4
  • Synonyms
    HM4, M4R
  • Links
    NCBI Gene ID: 1132
    neXtProt AC: NX_P08173
    UniProt: P08173

  • Chr Location
    11p11.2; chr11:46383789-46391776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show decreased body weight, hyperactivity, abnormalities in carbamylcholine-induced bradycardia and gallbladder contractility, and altered CNS synaptic transmission. Mice homozygous for a different null allele show loss of the anti-cataleptic effect of scopolamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    140
  • cDNA Data
    5
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040495 Ensembl Gene Model | MGI Sequence Detail 1440 C57BL/6J ±  kb
    transcript ENSMUST00000045537 Ensembl | MGI Sequence Detail 1440 Not Applicable  
    polypeptide ENSMUSP00000040808 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001616 muscarinic acetylcholine receptor M4
      (term hierarchy)
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR000995 Muscarinic acetylcholine receptor family
      IPR001432 Muscarinic acetylcholine receptor M4
    • GlyGen
      P32211 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 4
      cDNA 5
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1977, MGD-MRK-1981
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 11
      Gene Ontology 5
      Phenotypes 73
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory