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Cdh15 Gene Detail
Summary
  • Symbol
    Cdh15
  • Name
    cadherin 15
  • Synonyms
    Cdh14, Mcad, M cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:106672
    NCBI Gene: 12555
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123575113-123594136 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.99 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    715 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106672
 protein coding gene Chr8:123574705-123594136 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034238
 protein coding gene Chr8:126416775-126435970 (+)
A/J MGP_AJ_G0034218
 protein coding gene Chr8:121186199-121205520 (+)
AKR/J MGP_AKRJ_G0034145
 protein coding gene Chr8:124723346-124743453 (+)
BALB/cJ MGP_BALBcJ_G0034212
 protein coding gene Chr8:121380649-121399843 (+)
C3H/HeJ MGP_C3HHeJ_G0033922
 protein coding gene Chr8:125417688-125436854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034731
 protein coding gene Chr8:130653766-130672919 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031673
 protein coding gene Chr8:114007905-114026171 (+)
CAST/EiJ MGP_CASTEiJ_G0033250
 protein coding gene Chr8:125494948-125515658 (+)
CBA/J MGP_CBAJ_G0033895
 protein coding gene Chr8:135444131-135463360 (+)
DBA/2J MGP_DBA2J_G0034052
 protein coding gene Chr8:120370258-120389411 (+)
FVB/NJ MGP_FVBNJ_G0033995
 protein coding gene Chr8:119520228-119539381 (+)
LP/J MGP_LPJ_G0034141
 protein coding gene Chr8:126545402-126564598 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034042
 protein coding gene Chr8:137588423-137607576 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034750
 protein coding gene Chr8:124896682-124915835 (+)
PWK/PhJ MGP_PWKPhJ_G0032951
 protein coding gene Chr8:120191381-120211034 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032791
 protein coding gene Chr8:123617653-123636833 (+)
WSB/EiJ MGP_WSBEiJ_G0033366
 protein coding gene Chr8:125653324-125673508 (+)



Homology
more
  • Human Ortholog
    CDH15, cadherin 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH15, cadherin 15
  • Synonyms
    CDH14, CDH3, CDHM, MCAD, MRD3
  • Links
    NCBI Gene ID: 1013
    neXtProt AC: NX_P55291
    UniProt: P55291

  • Chr Location
    16q24.3; chr16:89171748-89195492 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CDH15 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Homozygous null mice are viable, fertile, and show no apparent defects in the development, maintenance, or regeneration of skeletal muscle or in the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    223
  • cDNA Data
    21
  • Literature Summary
    27
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12555 NCBI Gene Model | MGI Sequence Detail 19024 C57BL/6J ±  kb
transcript NM_007662 RefSeq | MGI Sequence Detail 2843 Not Specified  
polypeptide P33146 UniProt | EBI | MGI Sequence Detail 784 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 21
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16328, MGD-MRK-19362, MGD-MRK-35131, MGI:2142505, MGI:99550
References
more
  • Summaries
    All 67
    Developmental Gene Expression 27
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:11403 Hatta M, et al., Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucleic Acids Res. 1991 Aug 25;19(16):4437-41
  • Latest
    J:305054 Lin YJ, et al., The cooperation of cis-elements during M-cadherin promoter activation. Biochem J. 2021 Feb 26;478(4):911-926
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory