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Tpo Gene Detail
Summary
  • Symbol
    Tpo
  • Name
    thyroid peroxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98813
    NCBI Gene: 22018
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:30104658-30182623 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.00 cM, cytoband C
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2411 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98813
 protein coding gene Chr12:30104658-30182983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019650
 protein coding gene Chr12:27947012-28019430 (-)
A/J MGP_AJ_G0019617
 protein coding gene Chr12:27176776-27247437 (-)
AKR/J MGP_AKRJ_G0019588
 protein coding gene Chr12:28068610-28139305 (-)
BALB/cJ MGP_BALBcJ_G0019594
 protein coding gene Chr12:27430687-27499309 (-)
C3H/HeJ MGP_C3HHeJ_G0019398
 protein coding gene Chr12:27918910-27988216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020041
 protein coding gene Chr12:28829739-28915087 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017666
 protein coding gene Chr12:26515419-26584827 (-)
CAST/EiJ MGP_CASTEiJ_G0018953
 protein coding gene Chr12:22912895-22990653 (-)
CBA/J MGP_CBAJ_G0019369
 protein coding gene Chr12:29787930-29860644 (-)
DBA/2J MGP_DBA2J_G0019483
 protein coding gene Chr12:27021325-27094310 (-)
FVB/NJ MGP_FVBNJ_G0019474
 protein coding gene Chr12:26833407-26903696 (-)
LP/J MGP_LPJ_G0019553
 protein coding gene Chr12:28040768-28109820 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019509
 protein coding gene Chr12:29393101-29462582 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020081
 protein coding gene Chr12:27593539-27676587 (-)
PWK/PhJ MGP_PWKPhJ_G0018720
 protein coding gene Chr12:21745120-21820131 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018508
 protein coding gene Chr12:22190822-22261958 (-)
WSB/EiJ MGP_WSBEiJ_G0019004
 protein coding gene Chr12:27806346-27881289 (-)



Homology
more
  • Human Ortholog
    TPO, thyroid peroxidase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPO, thyroid peroxidase
  • Synonyms
    MSA, TDH2A, TPX
  • Links
    NCBI Gene ID: 7173
    neXtProt AC: NX_P07202
    UniProt: P07202

  • Chr Location
    2p25.3; chr2:1374047-1543711 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tpo mouse models; 3 with human TPO associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 4 alleles in 5 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice with a missense mutation exhibit hypothyroid dwarfism, including a goiter with colloid deficiency and abnormal follicle epithelium, reduced hematocrit and red blood cells and a lifespan of about 3 months.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    104
  • cDNA Data
    13
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020673 Ensembl Gene Model | MGI Sequence Detail 77966 C57BL/6J ±  kb
    transcript ENSMUST00000021005 Ensembl | MGI Sequence Detail 3299 Not Applicable  
    polypeptide ENSMUSP00000021005 Ensembl | MGI Sequence Detail 914 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 16
      Primer pair 4
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15209
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 12
      Phenotypes 10
    • Earliest
      J:42190 Burrow GN, et al., Normal peroxidase activity in Pendred's syndrome. J Clin Endocrinol Metab. 1973 Mar;36(3):522-30
    • Latest
      J:348286 Zhang Z, et al., Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis. Nat Commun. 2024 May 15;15(1):4108
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory