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Thbs1 Gene Detail
Summary
  • Symbol
    Thbs1
  • Name
    thrombospondin 1
  • Synonyms
    tbsp1, Thbs-1, TSP-1, TSP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98737
    NCBI Gene: 21825
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:117942357-117957614 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.34 cM, cytoband F1-F3
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98737
 protein coding gene Chr2:117942357-117957614 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026311
 protein coding gene Chr2:120786393-120801608 (+)
A/J MGP_AJ_G0026272
 protein coding gene Chr2:115876514-115891740 (+)
AKR/J MGP_AKRJ_G0026251
 protein coding gene Chr2:119130456-119145717 (+)
BALB/cJ MGP_BALBcJ_G0026285
 protein coding gene Chr2:116133754-116148962 (+)
C3H/HeJ MGP_C3HHeJ_G0026031
 protein coding gene Chr2:119585909-119601123 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026732
 protein coding gene Chr2:124765217-124780474 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024112
 protein coding gene Chr2:110927946-110943089 (+)
CAST/EiJ MGP_CASTEiJ_G0025493
 protein coding gene Chr2:119889667-119943590 (+)
CBA/J MGP_CBAJ_G0026007
 protein coding gene Chr2:129175594-129190846 (+)
DBA/2J MGP_DBA2J_G0026146
 protein coding gene Chr2:115301778-115316994 (+)
FVB/NJ MGP_FVBNJ_G0026108
 protein coding gene Chr2:114126066-114141255 (+)
LP/J MGP_LPJ_G0026247
 protein coding gene Chr2:121107893-121123110 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026127
 protein coding gene Chr2:133569296-133584490 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026787
 protein coding gene Chr2:119245702-119260918 (+)
PWK/PhJ MGP_PWKPhJ_G0025229
 protein coding gene Chr2:114847946-114863418 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025028
 protein coding gene Chr2:118403885-118419155 (+)
WSB/EiJ MGP_WSBEiJ_G0025562
 protein coding gene Chr2:120061981-120077230 (+)



Homology
more
  • Human Ortholog
    THBS1, thrombospondin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THBS1, thrombospondin 1
  • Synonyms
    THBS, THBS-1, TSP, TSP-1, TSP1
  • Links
    NCBI Gene ID: 7057
    neXtProt AC: NX_P07996
    UniProt: P07996

  • Chr Location
    15q14; chr15:39581079-39599466 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Thbs1 mouse models; 4 with human THBS1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 2 alleles in 4 genetic backgrounds
    32 phenotypes from multigenic genotypes
    2 images
    168 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show partial prenatal lethality, lordosis, kyphosis, leukocytosis, multiorgan inflammation, lung hemorrhage, pneumonia, resistance to radiation and ischemic injury, altered blood pressure and vasoactive stress responses, eye pathology, and corneal and lacrimal gland dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    109
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1228
  • Tissues
    226
  • cDNA Data
    414
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21825 NCBI Gene Model | MGI Sequence Detail 15258 C57BL/6J ±  kb
    transcript NM_011580 RefSeq | MGI Sequence Detail 5865 ZRU/MplStud  
    polypeptide P35441 UniProt | EBI | MGI Sequence Detail 1170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 434
      Genomic 6
      cDNA 418
      Primer pair 7
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15083, MGD-MRK-15086
    References
    more
    • Summaries
      All 336
      Developmental Gene Expression 47
      Diseases 1
      Gene Ontology 24
      Phenotypes 168
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353517 Ko JH, et al., Splenocytes with fucosylation deficiency promote T cell proliferation and differentiation through thrombospondin-1 downregulation. Immunology. 2024 Feb;171(2):262-269
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory