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Prdx1 Gene Detail
Summary
  • Symbol
    Prdx1
  • Name
    peroxiredoxin 1
  • Synonyms
    macrophage 23kDa stress protein, macrophase stress protein 22kDa, MSP23, OSF-3, osteoblast specific factor 3, PAG, Paga, prx1, Prx I, PrxI, Tdpx2, TDX2, thioredoxin dependent peroxide reductase 2, Trx dependent peroxide reductase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99523
    NCBI Gene: 18477
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116542796-116557196 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.28 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99523
 protein coding gene Chr4:116542741-116558019 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028631
 protein coding gene Chr4:117598937-117612610 (+)
A/J MGP_AJ_G0028592
 protein coding gene Chr4:113086678-113101688 (+)
AKR/J MGP_AKRJ_G0028542
 protein coding gene Chr4:115534085-115550439 (+)
BALB/cJ MGP_BALBcJ_G0028613
 protein coding gene Chr4:113711644-113726924 (+)
C3H/HeJ MGP_C3HHeJ_G0028327
 protein coding gene Chr4:117101331-117114987 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029054
 protein coding gene Chr4:122152825-122168095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026338
 protein coding gene Chr4:107127062-107141997 (+)
CAST/EiJ MGP_CASTEiJ_G0027761
 protein coding gene Chr4:114329583-114345273 (+)
CBA/J MGP_CBAJ_G0028294
 protein coding gene Chr4:125455171-125471350 (+)
DBA/2J MGP_DBA2J_G0028442
 protein coding gene Chr4:113719466-113734701 (+)
FVB/NJ MGP_FVBNJ_G0028410
 protein coding gene Chr4:112218351-112236305 (+)
LP/J MGP_LPJ_G0028544
 protein coding gene Chr4:117801742-117819308 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028437
 protein coding gene Chr4:130446584-130468771 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029091
 protein coding gene Chr4:116685817-116700983 (+)
PWK/PhJ MGP_PWKPhJ_G0027487
 protein coding gene Chr4:110496773-110511601 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027310
 protein coding gene Chr4:112959628-112975743 (+)
WSB/EiJ MGP_WSBEiJ_G0027840
 protein coding gene Chr4:116559503-116575371 (+)



Homology
more
  • Human Ortholog
    PRDX1, peroxiredoxin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDX1, peroxiredoxin 1
  • Synonyms
    MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2
  • Links
    NCBI Gene ID: 5052
    neXtProt AC: NX_Q06830
    UniProt: Q06830

  • Chr Location
    1p34.1; chr1:45510914-45542732 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 4 alleles in 4 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice exhibit defects in antioxidant defense that manifest as hemolytic anemia and malignancies. The phenotype is more severe in homozygous mutant mice, which die prematurely. Homozygous KO reduces susceptibility to chemically induced skin cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    882
  • Tissues
    155
  • cDNA Data
    24
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18477 NCBI Gene Model | MGI Sequence Detail 14401 C57BL/6J ±  kb
    transcript NM_011034 RefSeq | MGI Sequence Detail 1416 ZRU/MplStud  
    polypeptide P35700 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 24
      Primer pair 6
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16300
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 13
      Gene Ontology 14
      Phenotypes 50
    • Earliest
      J:14699 Ishii T, et al., Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J Biol Chem. 1993 Sep 5;268(25):18633-6
    • Latest
      J:352214 Li L, et al., Conditional knockout mouse model reveals a critical role of peroxiredoxin 1 in oral leukoplakia carcinogenesis. Heliyon. 2024 May 30;10(10):e31227
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory