Fgf7 MGI Mouse Gene Detail - MGI:95521 - fibroblast growth factor 7

Symbol

Fgf7
Name

fibroblast growth factor 7
Synonyms

Keratinocyte growth factor, Kgf

Feature Type

protein coding gene
IDs

MGI:95521
NCBI Gene: 14178
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:125876578-125933105 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM, cytoband F-G
Mapping Data

4 experiments

SNPs within 2kb

1166 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95521	protein coding gene	Chr2:125876578-125933105 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026437	protein coding gene	Chr2:129234628-129291134 (+)
A/J	MGP_AJ_G0026400	protein coding gene	Chr2:123981845-124040903 (+)
AKR/J	MGP_AKRJ_G0026376	protein coding gene	Chr2:127530600-127591825 (+)
BALB/cJ	MGP_BALBcJ_G0026412	protein coding gene	Chr2:124268139-124324963 (+)
C3H/HeJ	MGP_C3HHeJ_G0026156	protein coding gene	Chr2:128016936-128084566 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026858	protein coding gene	Chr2:133362407-133421541 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024235	protein coding gene	Chr2:118755669-118812002 (+)
CAST/EiJ	MGP_CASTEiJ_G0025617	protein coding gene	Chr2:128264894-128327234 (+)
CBA/J	MGP_CBAJ_G0026136	protein coding gene	Chr2:138208239-138274476 (+)
DBA/2J	MGP_DBA2J_G0026270	protein coding gene	Chr2:123401901-123459449 (+)
FVB/NJ	MGP_FVBNJ_G0026234	protein coding gene	Chr2:122074728-122133848 (+)
LP/J	MGP_LPJ_G0026375	protein coding gene	Chr2:129470780-129528492 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026254	protein coding gene	Chr2:142296127-142363374 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026913	protein coding gene	Chr2:127565447-127624895 (+)
PWK/PhJ	MGP_PWKPhJ_G0025353	protein coding gene	Chr2:122950684-123009719 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025155	protein coding gene	Chr2:126643699-126700875 (+)
WSB/EiJ	MGP_WSBEiJ_G0025691	protein coding gene	Chr2:128458888-128521866 (+)

Human Ortholog

FGF7, fibroblast growth factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGF7, fibroblast growth factor 7
Synonyms

HBGF-7, KGF
Links

HGNC:3685

NCBI Gene ID: 2252

neXtProt AC: NX_P21781

UniProt: P21781
Chr Location

15q21.2; chr15:49423237-49488775 (+) GRCh38

MGI Vertebrate Homology

Fgf7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGF7
Gene Tree

Fgf7

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Phenotype Summary

34 phenotypes from 2 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Fgf7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal coat appearance, kidney dysplasia, spleen hypoplasia, abnormal synaptic vesicle clustering and miniature inhibitory postsynaptic currents, increased susceptibility to drug-induced seizures, and impaired thymic recovery after injury.

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All GO Annotations

66
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1368
Tissues

426
cDNA Data

15
Literature Summary

107

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FGF7

Xenbase fgf7

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS16681.1

Ensembl

ENSMUSG00000027208 (Evidence)
NCBI Gene

14178

			Length	Strain/Species	Flank
genomic	14178	NCBI Gene Model \| MGI Sequence Detail	56528	C57BL/6J	± kb
transcript	NM_008008	RefSeq \| MGI Sequence Detail	2672	C57BL/6
polypeptide	P36363	UniProt \| EBI \| MGI Sequence Detail	194	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007498 fibroblast growth factor 7

(term hierarchy)
InterPro Domains

IPR008996 Cytokine IL1/FGF

IPR002209 Fibroblast growth factor family
GlyGen

P36363 1 site

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All nucleic 51

Genomic 2

cDNA 19

Primer pair 21

Other 9

Microarray probesets 4

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MGD-MRK-9772

Summaries

All 199

Developmental Gene Expression 107

Gene Ontology 15

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Fgf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19920	Chr2:125876477-125876493 (+)	-93 bp
Tssr19921	Chr2:125876557-125876566 (+)	-16 bp
Tssr19922	Chr2:125876567-125876585 (+)	-2 bp
Tssr19923	Chr2:125876586-125876599 (+)	15 bp
Tssr19924	Chr2:125876685-125876714 (+)	122 bp
Tssr19925	Chr2:125876715-125876728 (+)	144 bp
Tssr19926	Chr2:125876887-125876900 (+)	316 bp
Tssr19927	Chr2:125877586-125877610 (+)	1,020 bp
Tssr19928	Chr2:125877615-125877644 (+)	1,052 bp
Tssr19929	Chr2:125877701-125877718 (+)	1,132 bp
Tssr19930	Chr2:125877845-125877860 (+)	1,275 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24