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Grik2 Gene Detail
Summary
  • Symbol
    Grik2
  • Name
    glutamate receptor, ionotropic, kainate 2 (beta 2)
  • Synonyms
    C130030K03Rik, Glur-6, Glur6, Glurbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95815
    NCBI Gene: 14806
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:48970929-49664862 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 24.87 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20057 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95815
 protein coding gene Chr10:48969776-49666523 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017211
 protein coding gene Chr10:48100211-48850758 (-)
A/J MGP_AJ_G0017187
 protein coding gene Chr10:46706937-47400536 (-)
AKR/J MGP_AKRJ_G0017146
 protein coding gene Chr10:47558492-48295019 (-)
BALB/cJ MGP_BALBcJ_G0017148
 protein coding gene Chr10:46865816-47575733 (-)
C3H/HeJ MGP_C3HHeJ_G0016972
 protein coding gene Chr10:47838918-48574511 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017606
 protein coding gene Chr10:49620848-50397240 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015301
 protein coding gene Chr10:44296487-44973031 (-)
CAST/EiJ MGP_CASTEiJ_G0016546
 protein coding gene Chr10:48010876-48755886 (-)
CBA/J MGP_CBAJ_G0016943
 protein coding gene Chr10:51818226-52636503 (-)
DBA/2J MGP_DBA2J_G0017048
 protein coding gene Chr10:46147585-46850952 (-)
FVB/NJ MGP_FVBNJ_G0017042
 protein coding gene Chr10:45573839-46257776 (-)
LP/J MGP_LPJ_G0017123
 protein coding gene Chr10:48200407-48912656 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017071
 protein coding gene Chr10:53191916-54266476 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017642
 protein coding gene Chr10:47552221-48292473 (-)
PWK/PhJ MGP_PWKPhJ_G0016325
 protein coding gene Chr10:46031540-46743947 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016110
 protein coding gene Chr10:47182643-47912282 (-)
WSB/EiJ MGP_WSBEiJ_G0016609
 protein coding gene Chr10:47782291-48524883 (-)



Homology
more
  • Human Ortholog
    GRIK2, glutamate ionotropic receptor kainate type subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIK2, glutamate ionotropic receptor kainate type subunit 2
  • Synonyms
    EAA4, GLR6, GluK2, GLUK6, GLUR6, MRT6, NEDLAS
  • Links
    NCBI Gene ID: 2898
    neXtProt AC: NX_Q13002
    UniProt: Q13002

  • Chr Location
    6q16.3; chr6:100962701-102081622 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GRIK2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit hippocampal neurons with reduced sensitivity to kainate and reduced susceptibility to the seizure-inducing effects of kainate administration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    122
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1000
  • Tissues
    116
  • cDNA Data
    14
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056073 Ensembl Gene Model | MGI Sequence Detail 693934 C57BL/6J ±  kb
    transcript ENSMUST00000105484 Ensembl | MGI Sequence Detail 3992 Not Applicable  
    polypeptide ENSMUSP00000101124 Ensembl | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008241 glutamate receptor ionotropic, kainate 2
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      P39087 10 sites, 12 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 17
      Primer pair 4
      Other 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10145, MGD-MRK-10152, MGD-MRK-10253, MGI:2143816, MGI:2444432
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 24
      Gene Ontology 42
      Phenotypes 61
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:340818 Nair JD, et al., GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors. iScience. 2023 Oct 20;26(10):107708
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory