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Man1a2 Gene Detail
Summary
  • Symbol
    Man1a2
  • Name
    mannosidase, alpha, class 1A, member 2
  • Synonyms
    Man1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104676
    NCBI Gene: 17156
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:100469519-100592789 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 43.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104676
 protein coding gene Chr3:100469519-100592819 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027668
 protein coding gene Chr3:101680411-101807637 (-)
A/J MGP_AJ_G0027627
 protein coding gene Chr3:98470637-98600013 (-)
AKR/J MGP_AKRJ_G0027593
 protein coding gene Chr3:100858000-100989652 (-)
BALB/cJ MGP_BALBcJ_G0027640
 protein coding gene Chr3:98234137-98361496 (-)
C3H/HeJ MGP_C3HHeJ_G0027369
 protein coding gene Chr3:101181667-101307764 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028083
 protein coding gene Chr3:105412920-105540616 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025424
 protein coding gene Chr3:94683827-94806402 (-)
CAST/EiJ MGP_CASTEiJ_G0026825
 protein coding gene Chr3:100287192-100413746 (-)
CBA/J MGP_CBAJ_G0027344
 protein coding gene Chr3:109016750-109156197 (-)
DBA/2J MGP_DBA2J_G0027487
 protein coding gene Chr3:97718005-97840646 (-)
FVB/NJ MGP_FVBNJ_G0027455
 protein coding gene Chr3:95652029-95774907 (-)
LP/J MGP_LPJ_G0027594
 protein coding gene Chr3:103041161-103170774 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027485
 protein coding gene Chr3:115269734-115405613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028138
 protein coding gene Chr3:100368609-100501615 (-)
PWK/PhJ MGP_PWKPhJ_G0026552
 protein coding gene Chr3:97472721-97595000 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026374
 protein coding gene Chr3:98474967-98601509 (-)
WSB/EiJ MGP_WSBEiJ_G0026905
 protein coding gene Chr3:100930398-101058183 (-)



Homology
more
  • Human Ortholog
    MAN1A2, mannosidase alpha class 1A member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAN1A2, mannosidase alpha class 1A member 2
  • Synonyms
    MAN1B
  • Links
    NCBI Gene ID: 10905
    neXtProt AC: NX_O60476
    UniProt: O60476

  • Chr Location
    1p12; chr1:117367449-117528872 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in respiratory distress and death within a few hours after birth. Lung development is delayed, the alveolar septum is thickened, and hemorrhage occurs in the alveolar region.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    220
  • cDNA Data
    191
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17156 NCBI Gene Model | MGI Sequence Detail 123271 C57BL/6J ±  kb
    transcript NM_010763 RefSeq | MGI Sequence Detail 7960 C57BL/6  
    polypeptide P39098 UniProt | EBI | MGI Sequence Detail 641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 200
      Genomic 4
      cDNA 191
      Primer pair 5

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-27039, MGI:2139702, MGI:2139752, MGI:2139837
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:17517 Herscovics A, et al., Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals. J Biol Chem. 1994 Apr 1;269(13):9864-71
    • Latest
      J:320849 Ningappa M, et al., Mechanisms of Impaired Lung Development and Ciliation in Mannosidase-1-Alpha-2 (Man1a2) Mutants. Front Physiol. 2021;12:658518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory