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Csf3r Gene Detail
Summary
  • Symbol
    Csf3r
  • Name
    colony stimulating factor 3 receptor
  • Synonyms
    Cd114, Csfgr, G-CSFR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339755
    NCBI Gene: 12986
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:125918343-125938233 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 59.77 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    558 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339755
 protein coding gene Chr4:125917241-125938233 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028767
 protein coding gene Chr4:127665868-127692255 (+)
A/J MGP_AJ_G0028726
 protein coding gene Chr4:122641834-122661800 (+)
AKR/J MGP_AKRJ_G0028679
 protein coding gene Chr4:126021317-126043696 (+)
BALB/cJ MGP_BALBcJ_G0028749
 protein coding gene Chr4:123226697-123247043 (+)
C3H/HeJ MGP_C3HHeJ_G0028463
 protein coding gene Chr4:126074692-126094863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029191
 protein coding gene Chr4:132548268-132570061 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026464
 protein coding gene Chr4:115794864-115815614 (+)
CAST/EiJ MGP_CASTEiJ_G0027896
 protein coding gene Chr4:124183951-124207781 (+)
CBA/J MGP_CBAJ_G0028429
 protein coding gene Chr4:135774382-135794402 (+)
DBA/2J MGP_DBA2J_G0028578
 protein coding gene Chr4:123108749-123129592 (+)
FVB/NJ MGP_FVBNJ_G0028545
 protein coding gene Chr4:121750021-121774714 (+)
LP/J MGP_LPJ_G0028679
 protein coding gene Chr4:127956556-127980220 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028571
 protein coding gene Chr4:140792242-140820366 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029229
 protein coding gene Chr4:126365882-126388565 (+)
PWK/PhJ MGP_PWKPhJ_G0027617
 protein coding gene Chr4:119563971-119589146 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027443
 protein coding gene Chr4:122174751-122199484 (+)
WSB/EiJ MGP_WSBEiJ_G0027976
 protein coding gene Chr4:126459676-126482232 (+)



Homology
more
  • Human Ortholog
    CSF3R, colony stimulating factor 3 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSF3R, colony stimulating factor 3 receptor
  • Synonyms
    CD114, GCSFR, SCN7
  • Links
    NCBI Gene ID: 1441
    neXtProt AC: NX_Q99062
    UniProt: Q99062

  • Chr Location
    1p34.3; chr1:36466043-36483314 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Csf3r mouse models; 7 with human CSF3R associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 9 genetic backgrounds
    11 phenotypes from multigenic genotypes
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced numbers of peripheral neutrophils, with fewer hematopoietic progenitors in bone marrow and impaired expansion and terminal differentiation of progenitors into granulocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    21
  • cDNA Data
    42
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028859 Ensembl Gene Model | MGI Sequence Detail 19891 C57BL/6J ±  kb
    transcript ENSMUST00000106162 Ensembl | MGI Sequence Detail 3481 Not Applicable  
    polypeptide ENSMUSP00000101768 Ensembl | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 3
      cDNA 42
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2190, MGI:88533
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 9
      Phenotypes 80
    • Earliest
      J:10454 Fukunaga R, et al., Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell. 1990 Apr 20;61(2):341-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory