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Slc1a2 Gene Detail
Summary
  • Symbol
    Slc1a2
  • Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 2
  • Synonyms
    1700091C19Rik, 2900019G14Rik, Eaat2, GLT-1, GLT1, MGLT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101931
    NCBI Gene: 20511
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:102489004-102621129 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3939 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101931
 protein coding gene Chr2:102488584-102621129 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026198
 protein coding gene Chr2:104583630-104721646 (+)
A/J MGP_AJ_G0026159
 protein coding gene Chr2:100287053-100419701 (+)
AKR/J MGP_AKRJ_G0026140
 protein coding gene Chr2:102997570-103130867 (+)
BALB/cJ MGP_BALBcJ_G0026168
 protein coding gene Chr2:100562123-100694513 (+)
C3H/HeJ MGP_C3HHeJ_G0025919
 protein coding gene Chr2:103363643-103500106 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026619
 protein coding gene Chr2:108102460-108245440 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024010
 protein coding gene Chr2:95962924-96093867 (+)
CAST/EiJ MGP_CASTEiJ_G0025384
 protein coding gene Chr2:103803831-103941718 (+)
CBA/J MGP_CBAJ_G0025897
 protein coding gene Chr2:111808500-111947587 (+)
DBA/2J MGP_DBA2J_G0026033
 protein coding gene Chr2:99847695-99980998 (+)
FVB/NJ MGP_FVBNJ_G0025996
 protein coding gene Chr2:98850179-98982339 (+)
LP/J MGP_LPJ_G0026137
 protein coding gene Chr2:104733841-104870498 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026022
 protein coding gene Chr2:115772700-115908176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026673
 protein coding gene Chr2:103219268-103351200 (+)
PWK/PhJ MGP_PWKPhJ_G0025119
 protein coding gene Chr2:99348160-99479759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024920
 protein coding gene Chr2:102438577-102584331 (+)
WSB/EiJ MGP_WSBEiJ_G0025451
 protein coding gene Chr2:103923199-104054584 (+)



Homology
more
  • Human Ortholog
    SLC1A2, solute carrier family 1 member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC1A2, solute carrier family 1 member 2
  • Synonyms
    DEE41, EAAT2, EIEE41, GLT-1, GLT1, HBGT
  • Links
    NCBI Gene ID: 6506
    neXtProt AC: NX_P43004
    UniProt: P43004

  • Chr Location
    11p13; chr11:35251205-35420507 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC1A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display spontaneous seizures often leading to death as well as a succeptibility to neuronal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1074
  • Tissues
    185
  • cDNA Data
    23
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005089 Ensembl Gene Model | MGI Sequence Detail 132126 C57BL/6J ±  kb
    transcript ENSMUST00000080210 Ensembl | MGI Sequence Detail 11595 Not Applicable  
    polypeptide ENSMUSP00000079100 Ensembl | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000014973 excitatory amino acid transporter 2
      (term hierarchy)
    • InterPro Domains
      IPR050746 Dicarboxylate/Amino Acid:Cation Symporter
      IPR001991 Sodium:dicarboxylate symporter
      IPR018107 Sodium:dicarboxylate symporter, conserved site
      IPR036458 Sodium:dicarboxylate symporter superfamily
    • GlyGen
      P43006 5 sites, 15 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 25
      Primer pair 5
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16275, MGD-MRK-18762, MGI:1920182, MGI:1926215, MGI:2138846
    References
    more
    • Summaries
      All 182
      Developmental Gene Expression 27
      Gene Ontology 26
      Phenotypes 62
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355386 Chongtham A, et al., Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration. Exp Neurol. 2024 Sep 24;382:114967
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory