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Klf1 Gene Detail
Summary
  • Symbol
    Klf1
  • Name
    Kruppel-like transcription factor 1 (erythroid)
  • Synonyms
    Eklf, Nan
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342771
    NCBI Gene: 16596
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85628611-85631920 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.30 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342771
 protein coding gene Chr8:85628557-85631924 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033878
 protein coding gene Chr8:85831721-85835090 (+)
A/J MGP_AJ_G0033861
 protein coding gene Chr8:82448435-82451804 (+)
AKR/J MGP_AKRJ_G0033787
 protein coding gene Chr8:84891334-84894703 (+)
BALB/cJ MGP_BALBcJ_G0033854
 protein coding gene Chr8:82574973-82578342 (+)
C3H/HeJ MGP_C3HHeJ_G0033564
 protein coding gene Chr8:85514626-85518634 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034374
 protein coding gene Chr8:89110194-89114145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031315
 protein coding gene Chr8:76241572-76244743 (+)
CAST/EiJ MGP_CASTEiJ_G0032894
 protein coding gene Chr8:84943872-84947246 (+)
CBA/J MGP_CBAJ_G0033540
 protein coding gene Chr8:92148981-92152350 (+)
DBA/2J MGP_DBA2J_G0033693
 protein coding gene Chr8:82087285-82090654 (+)
FVB/NJ MGP_FVBNJ_G0033641
 protein coding gene Chr8:81031074-81034443 (+)
LP/J MGP_LPJ_G0033785
 protein coding gene Chr8:85939813-85943182 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033683
 protein coding gene Chr8:94706152-94709521 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034391
 protein coding gene Chr8:84877164-84882744 (+)
PWK/PhJ MGP_PWKPhJ_G0032598
 protein coding gene Chr8:81333560-81336930 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032434
 protein coding gene Chr8:83691988-83695371 (+)
WSB/EiJ MGP_WSBEiJ_G0033007
 protein coding gene Chr8:85310717-85314086 (+)



Homology
more
  • Human Ortholog
    KLF1, KLF transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF1, KLF transcription factor 1
  • Synonyms
    CDAN4A, CDAN4B, EKLF, EKLF/KLF1
  • Links
    NCBI Gene ID: 10661
    neXtProt AC: NX_Q13351
    UniProt: Q13351

  • Chr Location
    19p13.13; chr19:12884422-12887201 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Klf1 mouse models; 1 with human KLF1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit fatal anemia due to impaired hemopoiesis in fetal liver. Homozygotes for an ENU-induced allele die at E10-11 with severely impaired hemopoiesis while surviving heterozygotes show hemolytic anemia with reduced RBC counts, hematocrit and hemoglobin, and altered RBC morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    841
  • Tissues
    51
  • cDNA Data
    33
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16596 NCBI Gene Model | MGI Sequence Detail 3310 C57BL/6J ±  kb
    transcript NM_010635 RefSeq | MGI Sequence Detail 1476 ZRU/MplStud  
    polypeptide P46099 UniProt | EBI | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      Genomic 7
      cDNA 33
      Primer pair 13
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12777, MGD-MRK-9345, MGI:95311, MGI:97278
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 42
      Diseases 2
      Gene Ontology 13
      Phenotypes 79
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:346489 Xue L, et al., Generation, characterization, and use of EKLF(Klf1)/CRE knock-in mice for cell-restricted analyses. Front Hematol. 2024;2
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory