Cdkn1b MGI Mouse Gene Detail - MGI:104565 - cyclin dependent kinase inhibitor 1B

Symbol

Cdkn1b
Name

cyclin dependent kinase inhibitor 1B
Synonyms

p27, p27Kip1

Feature Type

protein coding gene
IDs

MGI:104565
NCBI Gene: 12576
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:134897364-134902476 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 65.77 cM
Mapping Data

4 experiments

SNPs within 2kb

132 from dbSNP Build 142
Strain Annotations

18
PCR

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104565	protein coding gene	Chr6:134897364-134902488 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031410	protein coding gene	Chr6:139221070-139226987 (+)
A/J	MGP_AJ_G0031386	protein coding gene	Chr6:133755945-133761070 (+)
AKR/J	MGP_AKRJ_G0031313	protein coding gene	Chr6:137813753-137819614 (+)
BALB/cJ	MGP_BALBcJ_G0031392	protein coding gene	Chr6:133570239-133575499 (+)
C3H/HeJ	MGP_C3HHeJ_G0031114	protein coding gene	Chr6:137857797-137864635 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031852	protein coding gene	Chr6:142998422-143005389 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028984	protein coding gene	Chr6:132899345-132904493 (+)
CAST/EiJ	MGP_CASTEiJ_G0030483	protein coding gene	Chr6:137272073-137278914 (+)
CBA/J	MGP_CBAJ_G0031073	protein coding gene	Chr6:148339976-148345108 (+)
DBA/2J	MGP_DBA2J_G0031231	protein coding gene	Chr6:132606613-132611936 (+)
FVB/NJ	MGP_FVBNJ_G0031181	protein coding gene	Chr6:131520071-131525184 (+)
LP/J	MGP_LPJ_G0031315	protein coding gene	Chr6:139325986-139330983 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031221	protein coding gene	Chr6:152363596-152381583 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031885	protein coding gene	Chr6:137551415-137558375 (+)
PWK/PhJ	MGP_PWKPhJ_G0030208	protein coding gene	Chr6:131097316-131103040 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030032	protein coding gene	Chr6:135725563-135730660 (+)
WSB/EiJ	MGP_WSBEiJ_G0030574	protein coding gene	Chr6:138183064-138190218 (+)

Human Ortholog

CDKN1B, cyclin dependent kinase inhibitor 1B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDKN1B, cyclin dependent kinase inhibitor 1B
Synonyms

CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Links

HGNC:1785

NCBI Gene ID: 1027

neXtProt AC: NX_P46527

UniProt: P46527
Chr Location

12p13.1; chr12:12685498-12722369 (+) GRCh38

MGI Vertebrate Homology

Cdkn1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CDKN1B
Gene Tree

Cdkn1b

Diseases

4 with human CDKN1B associations

				Human Disease	Mouse Models
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				multiple endocrine neoplasia type 4 IDs multiple endocrine neoplasia type 4 DOID:0080137 MESH:C567059 OMIM:610755
				myelodysplastic syndrome IDs myelodysplastic syndrome DOID:0050908 MESH:D009190 OMIM:614286 UMLS_CUI:C2713368

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

93 phenotypes from 9 alleles in 9 genetic backgrounds
127 phenotypes from multigenic genotypes
291 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

8
Gene trapped

2
Targeted

15
Transgenic

2
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants have increased body weight, enlargement of major organs, impaired hearing and increased tumor susceptibility. Females are sterile, having impaired luteal cell differentiation and disrupted estrus cycle.

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All GO Annotations

111
GO References

31

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1267
Tissues

239
cDNA Data

42
Literature Summary

427

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDKN1B

ZFIN cdkn1ba, cdkn1bb

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All Sequences

49
RefSeq

2
UniProt

4
CCDS

CCDS20642.1

Ensembl

ENSMUSG00000003031 (Evidence)
NCBI Gene

12576

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003031	Ensembl Gene Model \| MGI Sequence Detail	5113	C57BL/6J	± kb
transcript	ENSMUST00000067327	Ensembl \| MGI Sequence Detail	4552	Not Applicable
polypeptide	ENSMUSP00000065832	Ensembl \| MGI Sequence Detail	197	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003090 cyclin-dependent kinase inhibitor 1B

(term hierarchy)
InterPro Domains

IPR003175 Cyclin-dependent kinase inhibitor domain

IPR044898 Cyclin-dependent kinase inhibitor domain superfamily
GlyGen

P46414 1 site, 1 N-linked glycan (1 site)

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All nucleic 68

Genomic 1

cDNA 45

Primer pair 21

Other 1

Microarray probesets 6

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MGD-MRK-25999, MGI:2141358, MGI:2141489

Summaries

All 852

Developmental Gene Expression 427

Diseases 2

Gene Ontology 31

Phenotypes 291
Earliest

J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
Latest

J:354051 Kagoshima H, et al., EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development. J Neurosci. 2024 Feb 14;44(7)

TSS for Cdkn1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59258	Chr6:134897370-134897397 (+)	20 bp
Tssr59259	Chr6:134897473-134897486 (+)	116 bp
Tssr59260	Chr6:134897614-134897638 (+)	262 bp
Tssr59261	Chr6:134897651-134897667 (+)	295 bp
Tssr59262	Chr6:134897675-134897689 (+)	318 bp
Tssr59263	Chr6:134898152-134898171 (+)	798 bp
Tssr59264	Chr6:134901506-134901530 (+)	4,154 bp
Tssr59265	Chr6:134901609-134901629 (+)	4,255 bp
Tssr59266	Chr6:134901845-134901889 (+)	4,503 bp
Tssr59267	Chr6:134902097-134902101 (+)	4,735 bp
Tssr59268	Chr6:134902266-134902271 (+)	4,905 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24