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Vps4b Gene Detail
Summary
  • Symbol
    Vps4b
  • Name
    vacuolar protein sorting 4B
  • Synonyms
    8030489C12Rik, Skd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100499
    NCBI Gene: 20479
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:106698518-106724455 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 50.10 cM, cytoband D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100499
 protein coding gene Chr1:106691801-106724458 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016373
 protein coding gene Chr1:108946996-108979715 (-)
A/J MGP_AJ_G0016357
 protein coding gene Chr1:105126729-105159453 (-)
AKR/J MGP_AKRJ_G0016317
 protein coding gene Chr1:107998983-108031709 (-)
BALB/cJ MGP_BALBcJ_G0016313
 protein coding gene Chr1:105223306-105256031 (-)
C3H/HeJ MGP_C3HHeJ_G0016140
 protein coding gene Chr1:108452050-108484773 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016772
 protein coding gene Chr1:113085496-113119546 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014490
 protein coding gene Chr1:99431946-99466206 (-)
CAST/EiJ MGP_CASTEiJ_G0015722
 protein coding gene Chr1:107376361-107408436 (-)
CBA/J MGP_CBAJ_G0016113
 protein coding gene Chr1:116955645-116989259 (-)
DBA/2J MGP_DBA2J_G0016218
 protein coding gene Chr1:104195943-104228653 (-)
FVB/NJ MGP_FVBNJ_G0016219
 protein coding gene Chr1:103127856-103160557 (-)
LP/J MGP_LPJ_G0016292
 protein coding gene Chr1:110182864-110217270 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016245
 protein coding gene Chr1:121362960-121396935 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016811
 protein coding gene Chr1:108089740-108122708 (-)
PWK/PhJ MGP_PWKPhJ_G0015510
 protein coding gene Chr1:103217466-103251171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015295
 protein coding gene Chr1:106744814-106777906 (-)
WSB/EiJ MGP_WSBEiJ_G0015785
 protein coding gene Chr1:107917309-107950103 (-)



Homology
more
  • Human Ortholog
    VPS4B, vacuolar protein sorting 4 homolog B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS4B, vacuolar protein sorting 4 homolog B
  • Synonyms
    MIG1, SKD1, SKD1B, VPS4-2
  • Links
    NCBI Gene ID: 9525
    neXtProt AC: NX_O75351
    UniProt: O75351

  • Chr Location
    18q21.33; chr18:63389190-63422483 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality at approximately E9.5 and show placental abnormalities. Mouse embryonic fibroblasts from mice heterozygous for Vps4a and Vps4b null alleles exhibit increased endo/lysosomal organelles with large multi-membrane structures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20479 NCBI Gene Model | MGI Sequence Detail 25938 C57BL/6J ±  kb
    transcript NM_009190 RefSeq | MGI Sequence Detail 3272 C57BL/6  
    polypeptide P46467 UniProt | EBI | MGI Sequence Detail 444 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2442405
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 27
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:339600 Hermosilla Aguayo V, et al., ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Dev Biol. 2023 Aug 10;503:25-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory