Ccr7 MGI Mouse Gene Detail - MGI:103011 - C-C motif chemokine receptor 7

Symbol

Ccr7
Name

C-C motif chemokine receptor 7
Synonyms

CD197, Cmkbr7, EBI1, Ebi1h

Feature Type

protein coding gene
IDs

MGI:103011
NCBI Gene: 12775
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:99035025-99045903 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.92 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

390 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103011	protein coding gene	Chr11:99035022-99045903 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019083	protein coding gene	Chr11:101787624-101800058 (-)
A/J	MGP_AJ_G0019051	protein coding gene	Chr11:97509501-97520378 (-)
AKR/J	MGP_AKRJ_G0019021	protein coding gene	Chr11:100530154-100541034 (-)
BALB/cJ	MGP_BALBcJ_G0019025	protein coding gene	Chr11:98001769-98013129 (-)
C3H/HeJ	MGP_C3HHeJ_G0018838	protein coding gene	Chr11:100677653-100689266 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019476	protein coding gene	Chr11:104917870-104930048 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017108	protein coding gene	Chr11:95068523-95079444 (-)
CAST/EiJ	MGP_CASTEiJ_G0018392	protein coding gene	Chr11:101676308-101688332 (-)
CBA/J	MGP_CBAJ_G0018809	protein coding gene	Chr11:109276842-109293343 (-)
DBA/2J	MGP_DBA2J_G0018917	protein coding gene	Chr11:97068335-97079488 (-)
FVB/NJ	MGP_FVBNJ_G0018906	protein coding gene	Chr11:96586735-96598215 (-)
LP/J	MGP_LPJ_G0018987	protein coding gene	Chr11:102261072-102271999 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018933	protein coding gene	Chr11:108981440-108992252 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019516	protein coding gene	Chr11:100889263-100899992 (-)
PWK/PhJ	MGP_PWKPhJ_G0018163	protein coding gene	Chr11:98128574-98139576 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017952	protein coding gene	Chr11:100649021-100659946 (-)
WSB/EiJ	MGP_WSBEiJ_G0018441	protein coding gene	Chr11:100858578-100871638 (-)

Human Ortholog

CCR7, C-C motif chemokine receptor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCR7, C-C motif chemokine receptor 7
Synonyms

BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
Links

HGNC:1608

NCBI Gene ID: 1236

neXtProt AC: NX_P32248

UniProt: P32248
Chr Location

17q21.2; chr17:40553769-40565472 (-) GRCh38

MGI Vertebrate Homology

Ccr7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCR7
Gene Tree

Ccr7

Diseases

1 with Ccr7 mouse models

Human Disease

Mouse Models

Sjogren's syndrome

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

50 phenotypes from 4 alleles in 8 genetic backgrounds
3 phenotypes from multigenic genotypes
259 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Endonuclease-mediated

5
Gene trapped

1
Targeted

6
Transgenic

1
Genomic Mutations

1 involving Ccr7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice exhibit an impaired primary immune response. Dendritic cells, B, T and T regulatory cells show impaired migration to the lymph nodes and secondary lymph organs exhibit morphological abnormalities. Lymphocytic infiltrates to the pancreas, lung and stomach are observed in aged mice.

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All GO Annotations

78
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

92
cDNA Data

22
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS25373.1

Ensembl

ENSMUSG00000037944 (Evidence)
NCBI Gene

12775

			Length	Strain/Species	Flank
genomic	12775	NCBI Gene Model \| MGI Sequence Detail	10879	C57BL/6J	± kb
transcript	NM_007719	RefSeq \| MGI Sequence Detail	1975	C57BL/6
polypeptide	P47774	UniProt \| EBI \| MGI Sequence Detail	378	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001203 C-C chemokine receptor type 7

(term hierarchy)
InterPro Domains

IPR001718 CC chemokine receptor 7

IPR000355 Chemokine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P47774 1 site

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All nucleic 26

cDNA 22

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-23848

Summaries

All 368

Developmental Gene Expression 8

Diseases 1

Gene Ontology 24

Phenotypes 259
Earliest

J:21104 Schweickart VL, et al., Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994 Oct;23(3):643-50
Latest

J:351006 Zhivaki D, et al., Correction of age-associated defects in dendritic cells enables CD4(+) T cells to eradicate tumors. Cell. 2024 Jun 12;

TSS for Ccr7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110630	Chr11:99045893-99045911 (-)	1 bp
Tssr110629	Chr11:99045844-99045863 (-)	49 bp
Tssr110628	Chr11:99044842-99044853 (-)	1,055 bp
Tssr110627	Chr11:99043082-99043088 (-)	2,818 bp
Tssr110626	Chr11:99035902-99035922 (-)	9,991 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24