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Map2k4 Gene Detail
Summary
  • Symbol
    Map2k4
  • Name
    mitogen-activated protein kinase kinase 4
  • Synonyms
    JNKK1, MKK4, Sek1, Serk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346869
    NCBI Gene: 26398
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:65579069-65679123 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 40.53 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2020 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346869
 protein coding gene Chr11:65579069-65679185 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018477
 protein coding gene Chr11:65899410-66007235 (-)
A/J MGP_AJ_G0018446
 protein coding gene Chr11:63453617-63555650 (-)
AKR/J MGP_AKRJ_G0018415
 protein coding gene Chr11:65349717-65449234 (-)
BALB/cJ MGP_BALBcJ_G0018417
 protein coding gene Chr11:63708497-63808225 (-)
C3H/HeJ MGP_C3HHeJ_G0018230
 protein coding gene Chr11:65353685-65456864 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018869
 protein coding gene Chr11:67908031-68010884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016513
 protein coding gene Chr11:60463872-60559997 (-)
CAST/EiJ MGP_CASTEiJ_G0017786
 protein coding gene Chr11:65568812-65676554 (-)
CBA/J MGP_CBAJ_G0018204
 protein coding gene Chr11:70865843-70981912 (-)
DBA/2J MGP_DBA2J_G0018313
 protein coding gene Chr11:62989829-63089539 (-)
FVB/NJ MGP_FVBNJ_G0018303
 protein coding gene Chr11:62649513-62752974 (-)
LP/J MGP_LPJ_G0018385
 protein coding gene Chr11:66420797-66529633 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018327
 protein coding gene Chr11:71759978-71876290 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018910
 protein coding gene Chr11:65580250-65684936 (-)
PWK/PhJ MGP_PWKPhJ_G0017560
 protein coding gene Chr11:63630769-63737045 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017350
 protein coding gene Chr11:65413762-65521822 (-)
WSB/EiJ MGP_WSBEiJ_G0017839
 protein coding gene Chr11:65175788-65279365 (-)



Homology
more
  • Human Ortholog
    MAP2K4, mitogen-activated protein kinase kinase 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP2K4, mitogen-activated protein kinase kinase 4
  • Synonyms
    JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
  • Links
    NCBI Gene ID: 6416
    neXtProt AC: NX_P45985
    UniProt: P45985

  • Chr Location
    17p12; chr17:12020829-12143830 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human MAP2K4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit abnormal liver development with a deficiency of parenchymal hepatocytes, severe anemia, and lethality before embryonic day 14.0.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    153
  • cDNA Data
    110
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033352 Ensembl Gene Model | MGI Sequence Detail 100055 C57BL/6J ±  kb
    transcript ENSMUST00000046963 Ensembl | MGI Sequence Detail 3695 Not Applicable  
    polypeptide ENSMUSP00000041282 Ensembl | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000003283 dual specificity mitogen-activated protein kinase kinase 4
      (term hierarchy)
    • EC
      2.7.12.2
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      P47809 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 111
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35660, MGI:107199
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 16
      Gene Ontology 15
      Phenotypes 35
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:333483 Itah Z, et al., HER2-driven breast cancer suppression by the JNK signaling pathway. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2218373120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory