Wee1 MGI Mouse Gene Detail - MGI:103075 - WEE 1 homolog 1 (S. pombe)

Symbol

Wee1
Name

WEE 1 homolog 1 (S. pombe)
Synonyms

Wee1A

Feature Type

protein coding gene
IDs

MGI:103075
NCBI Gene: 22390
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:109721266-109742506 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.70 cM
Mapping Data

4 experiments

SNPs within 2kb

475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103075	protein coding gene	Chr7:109721253-109742506 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032855	protein coding gene	Chr7:113586965-113606736 (+)
A/J	MGP_AJ_G0032839	protein coding gene	Chr7:110770617-110791199 (+)
AKR/J	MGP_AKRJ_G0032770	protein coding gene	Chr7:113558549-113579905 (+)
BALB/cJ	MGP_BALBcJ_G0032843	protein coding gene	Chr7:110468875-110488769 (+)
C3H/HeJ	MGP_C3HHeJ_G0032553	protein coding gene	Chr7:113587175-113606873 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033349	protein coding gene	Chr7:118296263-118317693 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030321	protein coding gene	Chr7:112352197-112372195 (+)
CAST/EiJ	MGP_CASTEiJ_G0031881	protein coding gene	Chr7:105147142-105168471 (+)
CBA/J	MGP_CBAJ_G0032526	protein coding gene	Chr7:122162745-122182503 (+)
DBA/2J	MGP_DBA2J_G0032678	protein coding gene	Chr7:108879849-108899682 (+)
FVB/NJ	MGP_FVBNJ_G0032631	protein coding gene	Chr7:108737077-108756988 (+)
LP/J	MGP_LPJ_G0032772	protein coding gene	Chr7:115122096-115145489 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032663	protein coding gene	Chr7:123814151-123835367 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033370	protein coding gene	Chr7:112568842-112589116 (+)
PWK/PhJ	MGP_PWKPhJ_G0031588	protein coding gene	Chr7:101699207-101719658 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031436	protein coding gene	Chr7:99270031-99289392 (+)
WSB/EiJ	MGP_WSBEiJ_G0031994	protein coding gene	Chr7:113423275-113444190 (+)

Human Ortholog

WEE1, WEE1 G2 checkpoint kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WEE1, WEE1 G2 checkpoint kinase
Synonyms

WEE1A, WEE1hu
Links

HGNC:12761

NCBI Gene ID: 7465

neXtProt AC: NX_P30291

UniProt: P30291
Chr Location

11p15.4; chr11:9573670-9593457 (+) GRCh38

MGI Vertebrate Homology

Wee1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WEE1
Protein SuperFamily

Wee1-like_protein_kinase
Gene Tree

Wee1

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Phenotype Summary

15 phenotypes from 4 alleles in 4 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

38
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

2 involving Wee1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption may exhibit embryonic lethality at E7. Mice homozygous for a knock-out allele exhibit lethality between E3.5 and E7.5 with reduced proliferation, increased apoptosis and abnormal G2/M checkpoint function.

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All GO Annotations

29
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

22
cDNA Data

86
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA WEE1

Xenbase wee1

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS21743.1

Ensembl

ENSMUSG00000031016 (Evidence)
NCBI Gene

22390

			Length	Strain/Species	Flank
genomic	22390	NCBI Gene Model \| MGI Sequence Detail	21241	C57BL/6J	± kb
transcript	NM_009516	RefSeq \| MGI Sequence Detail	3419	C57BL/6
polypeptide	P47810	UniProt \| EBI \| MGI Sequence Detail	646	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000017403 Wee1-like protein kinase

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR050339 Cell Cycle and Stress Response Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR017164 Wee1-like protein kinase

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All nucleic 90

Genomic 1

cDNA 88

Primer pair 1

Microarray probesets 4

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MGD-MRK-23939

Summaries

All 72

Developmental Gene Expression 11

Gene Ontology 10

Phenotypes 26
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Wee1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68487	Chr7:109721240-109721342 (+)	25 bp
Tssr68488	Chr7:109721460-109721502 (+)	215 bp
Tssr68489	Chr7:109721506-109721530 (+)	252 bp
Tssr68490	Chr7:109721714-109721786 (+)	484 bp
Tssr68491	Chr7:109721926-109721985 (+)	690 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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