Igfbp1 MGI Mouse Gene Detail - MGI:96436 - insulin-like growth factor binding protein 1

Symbol

Igfbp1
Name

insulin-like growth factor binding protein 1
Synonyms

IGFBP-1

Feature Type

protein coding gene
IDs

MGI:96436
NCBI Gene: 16006
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:7147787-7152546 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 4.75 cM
Mapping Data

7 experiments

SNPs within 2kb

255 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96436	protein coding gene	Chr11:7147782-7152546 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018033	protein coding gene	Chr11:4398227-4402943 (+)
A/J	MGP_AJ_G0018006	protein coding gene	Chr11:4177918-4182576 (+)
AKR/J	MGP_AKRJ_G0017970	protein coding gene	Chr11:4373811-4378469 (+)
BALB/cJ	MGP_BALBcJ_G0017974	protein coding gene	Chr11:4177078-4181794 (+)
C3H/HeJ	MGP_C3HHeJ_G0017787	protein coding gene	Chr11:4277796-4282597 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018426	protein coding gene	Chr11:4483212-4487928 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016084	protein coding gene	Chr11:4048437-4052980 (+)
CAST/EiJ	MGP_CASTEiJ_G0017349	protein coding gene	Chr11:4270076-4274857 (+)
CBA/J	MGP_CBAJ_G0017762	protein coding gene	Chr11:4978094-4982810 (+)
DBA/2J	MGP_DBA2J_G0017872	protein coding gene	Chr11:4094458-4099174 (+)
FVB/NJ	MGP_FVBNJ_G0017864	protein coding gene	Chr11:4135684-4140485 (+)
LP/J	MGP_LPJ_G0017943	protein coding gene	Chr11:4451909-4456625 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017890	protein coding gene	Chr11:4512399-4517057 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018466	protein coding gene	Chr11:4426304-4431020 (+)
PWK/PhJ	MGP_PWKPhJ_G0017129	protein coding gene	Chr11:4136057-4140838 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016926	protein coding gene	Chr11:4349770-4354451 (+)
WSB/EiJ	MGP_WSBEiJ_G0017403	protein coding gene	Chr11:4232808-4237572 (+)

Human Ortholog

IGFBP1, insulin like growth factor binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IGFBP1, insulin like growth factor binding protein 1
Synonyms

AFBP, hIGFBP-1, IBP1, IGF-BP25, PP12
Links

HGNC:5469

NCBI Gene ID: 3484

neXtProt AC: NX_P08833

UniProt: P08833
Chr Location

7p12.3; chr7:45888360-45893660 (+) GRCh38

MGI Vertebrate Homology

Igfbp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IGFBP1
Gene Tree

Igfbp1

Diseases

1 with human IGFBP1 associations

				Human Disease	Mouse Models
				diabetic angiopathy IDs diabetic angiopathy DOID:11713 MESH:D003925 NCI:C35610 UMLS_CUI:C0011871 UMLS_CUI:C0011875

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene desplay a grossly normal phenotype but are more susceptible to liver injury.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

42
cDNA Data

45
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IGFBP1

Xenbase igfbp1

ZFIN igfbp1a, igfbp1b

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS24427.1

Ensembl

ENSMUSG00000020429 (Evidence)
NCBI Gene

16006

			Length	Strain/Species	Flank
genomic	16006	NCBI Gene Model \| MGI Sequence Detail	4760	C57BL/6J	± kb
transcript	NM_008341	RefSeq \| MGI Sequence Detail	1522	ZRU/MplStud
polypeptide	P47876	UniProt \| EBI \| MGI Sequence Detail	272	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008947 insulin-like growth factor-binding protein 1

(term hierarchy)
InterPro Domains

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR022322 Insulin-like growth factor-binding protein 1

IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site

IPR000716 Thyroglobulin type-1

IPR036857 Thyroglobulin type-1 superfamily

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All nucleic 103

Genomic 48

cDNA 46

Primer pair 9

Microarray probesets 4

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MGD-MRK-11233

Summaries

All 104

Developmental Gene Expression 39

Gene Ontology 7

Phenotypes 11
Earliest

J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Igfbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100294	Chr11:7147650-7147656 (+)	-134 bp
Tssr100295	Chr11:7147780-7147795 (+)	1 bp
Tssr100296	Chr11:7147804-7147811 (+)	21 bp
Tssr100297	Chr11:7147832-7147839 (+)	49 bp
Tssr100298	Chr11:7147852-7147854 (+)	66 bp
Tssr3421	Chr11:7149820-7149828 (+)	2,037 bp
Tssr100299	Chr11:7149853-7149856 (+)	2,068 bp
Tssr100300	Chr11:7149884-7149894 (+)	2,102 bp
Tssr100301	Chr11:7151972-7151983 (+)	4,191 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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