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Mt4 Gene Detail
Summary
  • Symbol
    Mt4
  • Name
    metallothionein 4
  • Synonyms
    MT-IV
  • Feature Type
    protein coding gene
  • IDs
    MGI:99692
    NCBI Gene: 17752
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94863832-94865659 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99692
 protein coding gene Chr8:94863825-94865659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033954
 protein coding gene Chr8:95533112-95534939 (+)
A/J MGP_AJ_G0033937
 protein coding gene Chr8:91818785-91820612 (+)
AKR/J MGP_AKRJ_G0033863
 protein coding gene Chr8:94339826-94341653 (+)
BALB/cJ MGP_BALBcJ_G0033929
 protein coding gene Chr8:91908340-91910167 (+)
C3H/HeJ MGP_C3HHeJ_G0033639
 protein coding gene Chr8:95040486-95042313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034450
 protein coding gene Chr8:99027231-99029058 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031391
 protein coding gene Chr8:85626529-85628663 (+)
CAST/EiJ MGP_CASTEiJ_G0032971
 protein coding gene Chr8:94627258-94629088 (+)
CBA/J MGP_CBAJ_G0033615
 protein coding gene Chr8:102312017-102313844 (+)
DBA/2J MGP_DBA2J_G0033769
 protein coding gene Chr8:91285497-91287324 (+)
FVB/NJ MGP_FVBNJ_G0033716
 protein coding gene Chr8:90254583-90256410 (+)
LP/J MGP_LPJ_G0033861
 protein coding gene Chr8:95685741-95687568 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033758
 protein coding gene Chr8:104610562-104612388 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034468
 protein coding gene Chr8:94490881-94492708 (+)
PWK/PhJ MGP_PWKPhJ_G0032673
 protein coding gene Chr8:90650321-90652151 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032510
 protein coding gene Chr8:93311472-93313304 (+)
WSB/EiJ MGP_WSBEiJ_G0033083
 protein coding gene Chr8:95005864-95007690 (+)



Homology
more
  • Human Ortholog
    MT4, metallothionein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MT4, metallothionein 4
  • Synonyms
    MT-4, MT-IV, MTIV
  • Links
    NCBI Gene ID: 84560
    neXtProt AC: NX_P47944
    UniProt: P47944

  • Chr Location
    16q13; chr16:56565073-56568957 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    11
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17752 NCBI Gene Model | MGI Sequence Detail 1828 C57BL/6J ±  kb
transcript NM_008631 RefSeq | MGI Sequence Detail 391 ZRU/MplStud  
polypeptide P47945 UniProt | EBI | MGI Sequence Detail 62 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 2
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16477
References
more
  • Summaries
    All 20
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:18736 Quaife CJ, et al., Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry. 1994 Jun 14;33(23):7250-9
  • Latest
    J:113477 Meloni G, et al., Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. J Biol Chem. 2006 May 26;281(21):14588-95
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory