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Syk Gene Detail
Summary
  • Symbol
    Syk
  • Name
    spleen tyrosine kinase
  • Synonyms
    Sykb
  • Feature Type
    protein coding gene
  • IDs
    MGI:99515
    NCBI Gene: 20963
  • Alliance
    gene page
  • Transcription Start Sites
    51 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:52737209-52802828 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 27.41 cM, cytoband B-C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99515
 protein coding gene Chr13:52736670-52802828 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020557
 protein coding gene Chr13:51860224-51926418 (+)
A/J MGP_AJ_G0020511
 protein coding gene Chr13:50007689-50073259 (+)
AKR/J MGP_AKRJ_G0020489
 protein coding gene Chr13:51431351-51497129 (+)
BALB/cJ MGP_BALBcJ_G0020507
 protein coding gene Chr13:50204940-50273032 (+)
C3H/HeJ MGP_C3HHeJ_G0020306
 protein coding gene Chr13:51269363-51340278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020941
 protein coding gene Chr13:53464132-53530884 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018523
 protein coding gene Chr13:47789420-47854407 (+)
CAST/EiJ MGP_CASTEiJ_G0019820
 protein coding gene Chr13:51265553-51374473 (+)
CBA/J MGP_CBAJ_G0020266
 protein coding gene Chr13:55470688-55539022 (+)
DBA/2J MGP_DBA2J_G0020389
 protein coding gene Chr13:49571609-49636692 (+)
FVB/NJ MGP_FVBNJ_G0020368
 protein coding gene Chr13:49014644-49080898 (+)
LP/J MGP_LPJ_G0020465
 protein coding gene Chr13:52136606-52206618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020397
 protein coding gene Chr13:55071601-55151747 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020984
 protein coding gene Chr13:51023842-51093637 (+)
PWK/PhJ MGP_PWKPhJ_G0019576
 protein coding gene Chr13:49509135-49613244 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019403
 protein coding gene Chr13:49868410-50019541 (+)
WSB/EiJ MGP_WSBEiJ_G0019882
 protein coding gene Chr13:51348269-51414347 (+)



Homology
more
  • Human Ortholog
    SYK, spleen associated tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYK, spleen associated tyrosine kinase
  • Synonyms
    IMD82, p72-Syk
  • Links
    NCBI Gene ID: 6850
    neXtProt AC: NX_P43405
    UniProt: P43405

  • Chr Location
    9q22.2; chr9:90801600-90898549 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SYK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 8 alleles in 16 genetic backgrounds
    41 phenotypes from multigenic genotypes
    173 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have high rates of postnatal lethality, exhibit developmental defects of B cells, T cells and osteoclasts, and have defective dendritic cell cross-presentation of antigens from necrotic cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    177
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    2
  • cDNA Data
    45
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021457 Ensembl Gene Model | MGI Sequence Detail 65620 C57BL/6J ±  kb
    transcript ENSMUST00000055087 Ensembl | MGI Sequence Detail 5122 Not Applicable  
    polypeptide ENSMUSP00000060828 Ensembl | MGI Sequence Detail 629 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 1
      cDNA 45

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-16292
    References
    more
    • Summaries
      All 318
      Developmental Gene Expression 16
      Gene Ontology 47
      Phenotypes 173
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory