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Gadd45a Gene Detail
Summary
  • Symbol
    Gadd45a
  • Name
    growth arrest and DNA-damage-inducible 45 alpha
  • Synonyms
    Ddit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107799
    NCBI Gene: 13197
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:67012080-67014391 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.72 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107799
 protein coding gene Chr6:67012080-67014441 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030843
 protein coding gene Chr6:67005268-67007629 (-)
A/J MGP_AJ_G0030813
 protein coding gene Chr6:64116209-64118570 (-)
AKR/J MGP_AKRJ_G0030741
 protein coding gene Chr6:66123626-66125987 (-)
BALB/cJ MGP_BALBcJ_G0030824
 protein coding gene Chr6:64491479-64493840 (-)
C3H/HeJ MGP_C3HHeJ_G0030888
 protein coding gene Chr6:118019846-118022207 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031282
 protein coding gene Chr6:68605733-68608094 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028471
 protein coding gene Chr6:61292738-61295114 (-)
CAST/EiJ MGP_CASTEiJ_G0029932
 protein coding gene Chr6:66405923-66411099 (-)
CBA/J MGP_CBAJ_G0030511
 protein coding gene Chr6:71428532-71430893 (-)
DBA/2J MGP_DBA2J_G0030663
 protein coding gene Chr6:63774912-63777273 (-)
FVB/NJ MGP_FVBNJ_G0030616
 protein coding gene Chr6:63284500-63286861 (-)
LP/J MGP_LPJ_G0030742
 protein coding gene Chr6:66936629-66938990 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030651
 protein coding gene Chr6:75139496-75141854 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031308
 protein coding gene Chr6:66040335-66042693 (-)
PWK/PhJ MGP_PWKPhJ_G0029647
 protein coding gene Chr6:62970818-62976370 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029476
 protein coding gene Chr6:65608599-65613875 (-)
WSB/EiJ MGP_WSBEiJ_G0030014
 protein coding gene Chr6:66360928-66363289 (-)



Homology
more
  • Human Ortholog
    GADD45A, growth arrest and DNA damage inducible alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GADD45A, growth arrest and DNA damage inducible alpha
  • Synonyms
    DDIT1, GADD45
  • Links
    NCBI Gene ID: 1647
    neXtProt AC: NX_P24522
    UniProt: P24522

  • Chr Location
    1p31.3; chr1:67685201-67688334 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gadd45a mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 1 allele in 3 genetic backgrounds
    36 phenotypes from multigenic genotypes
    2 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show genomic instability, thymus hyperplasia, elevated radiation carcinogenesis, abnormal parturition and low frequency exencephaly. Females develop a lupus-like syndrome associated with high titers of autoantibodies, hematologic deficits, glomerulonephritis and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    82
  • cDNA Data
    32
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13197 NCBI Gene Model | MGI Sequence Detail 2312 C57BL/6J ±  kb
    transcript NM_007836 RefSeq | MGI Sequence Detail 1224 129/Sv  
    polypeptide P48316 UniProt | EBI | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007787 growth arrest and DNA damage-inducible protein GADD45 alpha
      (term hierarchy)
    • InterPro Domains
      IPR024824 Growth arrest and DNA damage-inducible protein GADD45
      IPR029064 Ribosomal protein eL30-like superfamily
      IPR004038 Ribosomal protein eL8/eL30/eS12/Gadd45
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 2
      cDNA 32
      Primer pair 11
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36376, MGI:2141368
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 25
      Diseases 2
      Gene Ontology 8
      Phenotypes 42
    • Earliest
      J:43671 Hollander MC, et al., Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem. 1993 Nov 15;268(32):24385-93
    • Latest
      J:345016 Penniman CM, et al., Loss of FoxOs in muscle increases strength and mitochondrial function during aging. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):243-259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory