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Kcnj9 Gene Detail
Summary
  • Symbol
    Kcnj9
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 9
  • Synonyms
    1700085N21Rik, Girk3, Kir3.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108007
    NCBI Gene: 16524
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:172148075-172156889 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.66 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108007
 protein coding gene Chr1:172148068-172156889 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016785
 protein coding gene Chr1:178180223-178188884 (-)
A/J MGP_AJ_G0016764
 protein coding gene Chr1:170886844-170895529 (-)
AKR/J MGP_AKRJ_G0016730
 protein coding gene Chr1:176049590-176058253 (-)
BALB/cJ MGP_BALBcJ_G0016725
 protein coding gene Chr1:171433043-171441711 (-)
C3H/HeJ MGP_C3HHeJ_G0016549
 protein coding gene Chr1:176623894-176632563 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017187
 protein coding gene Chr1:184095195-184104012 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014893
 protein coding gene Chr1:162590071-162598948 (-)
CAST/EiJ MGP_CASTEiJ_G0016129
 protein coding gene Chr1:175994127-176002899 (-)
CBA/J MGP_CBAJ_G0016523
 protein coding gene Chr1:190638496-190647157 (-)
DBA/2J MGP_DBA2J_G0016630
 protein coding gene Chr1:169823716-169832379 (-)
FVB/NJ MGP_FVBNJ_G0016627
 protein coding gene Chr1:168078942-168087764 (-)
LP/J MGP_LPJ_G0016701
 protein coding gene Chr1:179270544-179279211 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016654
 protein coding gene Chr1:197885924-197894592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017223
 protein coding gene Chr1:175919139-175927809 (-)
PWK/PhJ MGP_PWKPhJ_G0015915
 protein coding gene Chr1:169199982-169208762 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015697
 protein coding gene Chr1:174870894-174879718 (-)
WSB/EiJ MGP_WSBEiJ_G0016191
 protein coding gene Chr1:176074644-176083314 (-)



Homology
more
  • Human Ortholog
    KCNJ9, potassium inwardly rectifying channel subfamily J member 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ9, potassium inwardly rectifying channel subfamily J member 9
  • Synonyms
    GIRK3, KIR3.3
  • Links
    NCBI Gene ID: 3765
    neXtProt AC: NX_Q92806
    UniProt: Q92806

  • Chr Location
    1q23.2; chr1:160081538-160090563 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus does not result in any overt phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    78
  • cDNA Data
    12
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16524 NCBI Gene Model | MGI Sequence Detail 8815 C57BL/6J ±  kb
transcript NM_001360808 RefSeq | MGI Sequence Detail 3914 ZRU/MplStud  
polypeptide P48543 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002004 G protein-activated inward rectifier potassium channel 3
    (term hierarchy)
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR041647 Inward rectifier potassium channel, C-terminal
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003276 Potassium channel, inwardly rectifying, Kir3.3
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
    IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
Molecular
Reagents
less
  • All nucleic 41
    Genomic 23
    cDNA 13
    Primer pair 5

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-37041, MGI:1920728
References
more
  • Summaries
    All 78
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:29320 Lesage F, et al., Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett. 1994 Oct 10;353(1):37-42
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory