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Pcnt Gene Detail
Summary
  • Symbol
    Pcnt
  • Name
    pericentrin (kendrin)
  • Synonyms
    m239Asp, m275Asp, mKIAA0402, Pcnt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102722
    NCBI Gene: 18541
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:76187097-76278620 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2075 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102722
 protein coding gene Chr10:76187097-76279988 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017381
 protein coding gene Chr10:76583540-76680271 (-)
A/J MGP_AJ_G0017358
 protein coding gene Chr10:73940873-74033806 (-)
AKR/J MGP_AKRJ_G0017319
 protein coding gene Chr10:75936464-76032256 (-)
BALB/cJ MGP_BALBcJ_G0017318
 protein coding gene Chr10:74146210-74238369 (-)
C3H/HeJ MGP_C3HHeJ_G0017142
 protein coding gene Chr10:76012549-76107304 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017776
 protein coding gene Chr10:79296100-79393783 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015466
 protein coding gene Chr10:70390891-70484183 (-)
CAST/EiJ MGP_CASTEiJ_G0016712
 protein coding gene Chr10:76321611-76421458 (-)
CBA/J MGP_CBAJ_G0017114
 protein coding gene Chr10:82393761-82495458 (-)
DBA/2J MGP_DBA2J_G0017219
 protein coding gene Chr10:73250634-73342911 (-)
FVB/NJ MGP_FVBNJ_G0017211
 protein coding gene Chr10:72406186-72498179 (-)
LP/J MGP_LPJ_G0017292
 protein coding gene Chr10:77089440-77180890 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017240
 protein coding gene Chr10:84458871-84554502 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017815
 protein coding gene Chr10:75989578-76086152 (-)
PWK/PhJ MGP_PWKPhJ_G0016496
 protein coding gene Chr10:73084440-73179127 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016279
 protein coding gene Chr10:75215302-75319024 (-)
WSB/EiJ MGP_WSBEiJ_G0016775
 protein coding gene Chr10:75971367-76067168 (-)



Homology
more
  • Human Ortholog
    PCNT, pericentrin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCNT, pericentrin
  • Synonyms
    KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4
  • Links
    NCBI Gene ID: 5116
    neXtProt AC: NX_O95613
    UniProt: O95613

  • Chr Location
    21q22.3; chr21:46324124-46445769 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pcnt mouse models; 1 with human PCNT associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 4 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele display mitotic spindle misorientation, microcephaly, craniofacial developmental anomalies, such as cleft palate and eye defects, variable structural kidney and cardiovascular defects, and altered hemodynamics leading to heart failure and prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1069
  • Tissues
    151
  • cDNA Data
    140
  • Literature Summary
    98
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001151 Ensembl Gene Model | MGI Sequence Detail 91524 C57BL/6J ±  kb
    transcript ENSMUST00000001179 Ensembl | MGI Sequence Detail 9331 Not Applicable  
    polypeptide ENSMUSP00000001179 Ensembl | MGI Sequence Detail 2916 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      Genomic 3
      cDNA 144
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-19626, MGI:2143839, MGI:2143946, MGI:3799283, MGI:3799287
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 98
      Diseases 3
      Gene Ontology 27
      Phenotypes 51
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory