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Fpgs Gene Detail
Summary
  • Symbol
    Fpgs
  • Name
    folylpolyglutamyl synthetase
  • Feature Type
    protein coding gene
  • IDs
    MGI:95576
    NCBI Gene: 14287
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:32572621-32594157 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    632 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95576
 protein coding gene Chr2:32572621-32594163 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025617
 protein coding gene Chr2:31162882-31188805 (-)
A/J MGP_AJ_G0025594
 protein coding gene Chr2:29834668-29856327 (-)
AKR/J MGP_AKRJ_G0025564
 protein coding gene Chr2:30901765-30928792 (-)
BALB/cJ MGP_BALBcJ_G0025591
 protein coding gene Chr2:29955590-29977316 (-)
C3H/HeJ MGP_C3HHeJ_G0025351
 protein coding gene Chr2:30786293-30808716 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026035
 protein coding gene Chr2:32105975-32128671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023444
 protein coding gene Chr2:28552786-28577545 (-)
CAST/EiJ MGP_CASTEiJ_G0024813
 protein coding gene Chr2:30731890-30757137 (-)
CBA/J MGP_CBAJ_G0025329
 protein coding gene Chr2:33330434-33358898 (-)
DBA/2J MGP_DBA2J_G0025462
 protein coding gene Chr2:29601313-29622805 (-)
FVB/NJ MGP_FVBNJ_G0025424
 protein coding gene Chr2:29479205-29502852 (-)
LP/J MGP_LPJ_G0025548
 protein coding gene Chr2:31037828-31060691 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025455
 protein coding gene Chr2:32953099-32979109 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026093
 protein coding gene Chr2:30775228-30799255 (-)
PWK/PhJ MGP_PWKPhJ_G0024561
 protein coding gene Chr2:29505480-29527991 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024361
 protein coding gene Chr2:30928596-30956550 (-)
WSB/EiJ MGP_WSBEiJ_G0024882
 protein coding gene Chr2:30952718-30978815 (-)



Homology
more
  • Human Ortholog
    FPGS, folylpolyglutamate synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FPGS, folylpolyglutamate synthase
  • Links
    NCBI Gene ID: 2356
    neXtProt AC: NX_Q05932
    UniProt: Q05932

  • Chr Location
    9q34.11; chr9:127794597-127814506 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    139
  • cDNA Data
    117
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009566 Ensembl Gene Model | MGI Sequence Detail 21537 C57BL/6J ±  kb
    transcript ENSMUST00000028148 Ensembl | MGI Sequence Detail 2273 Not Applicable  
    polypeptide ENSMUSP00000028148 Ensembl | MGI Sequence Detail 587 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 123
      Genomic 3
      cDNA 117
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9869, MGI:2138750
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:7037 Fournier RE, et al., Complementation mapping in microcell hybrids: localization of Fpgs and Ak-1 on Mus musculus chromosome 2. Somatic Cell Genet. 1983 Jan;9(1):69-84
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory