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Ptpre Gene Detail
Summary
  • Symbol
    Ptpre
  • Name
    protein tyrosine phosphatase receptor type E
  • Synonyms
    PTPe, PTPepsilon, RPTPepsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:97813
    NCBI Gene: 19267
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:135139210-135288022 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 81.27 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4592 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97813
 protein coding gene Chr7:135139195-135288023 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033135
 protein coding gene Chr7:140388720-140548527 (+)
A/J MGP_AJ_G0033117
 protein coding gene Chr7:136520842-136617493 (+)
AKR/J MGP_AKRJ_G0033049
 protein coding gene Chr7:140189806-140287937 (+)
BALB/cJ MGP_BALBcJ_G0033118
 protein coding gene Chr7:136281040-136376414 (+)
C3H/HeJ MGP_C3HHeJ_G0032832
 protein coding gene Chr7:140049925-140148338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033629
 protein coding gene Chr7:145704493-145858949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030602
 protein coding gene Chr7:137702181-137852211 (+)
CAST/EiJ MGP_CASTEiJ_G0032162
 protein coding gene Chr7:132105767-132266729 (+)
CBA/J MGP_CBAJ_G0032805
 protein coding gene Chr7:150659174-150755948 (+)
DBA/2J MGP_DBA2J_G0032957
 protein coding gene Chr7:134529891-134625696 (+)
FVB/NJ MGP_FVBNJ_G0032909
 protein coding gene Chr7:134280329-134475178 (+)
LP/J MGP_LPJ_G0033051
 protein coding gene Chr7:141911112-142082518 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032942
 protein coding gene Chr7:151440969-151604676 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033649
 protein coding gene Chr7:139210201-139321251 (+)
PWK/PhJ MGP_PWKPhJ_G0031868
 protein coding gene Chr7:127548704-127702006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031714
 protein coding gene Chr7:125947174-126102497 (+)
WSB/EiJ MGP_WSBEiJ_G0032273
 protein coding gene Chr7:140002659-140170703 (+)



Homology
more
  • Human Ortholog
    PTPRE, protein tyrosine phosphatase receptor type E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRE, protein tyrosine phosphatase receptor type E
  • Synonyms
    HPTPE, PTPE, R-PTP-EPSILON
  • Links
    NCBI Gene ID: 5791
    neXtProt AC: NX_P23469
    UniProt: P23469

  • Chr Location
    10q26.2; chr10:127907103-128085855 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit early-onset peripheral myelination defects, increased activity of voltage-gated potassium channels in Schwann cells, and increased trabecular bone mass due to cell-specific defects in osteoclast function in young females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    5
  • cDNA Data
    56
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041836 Ensembl Gene Model | MGI Sequence Detail 148813 C57BL/6J ±  kb
    transcript ENSMUST00000209256 Ensembl | MGI Sequence Detail 2593 Not Applicable  
    polypeptide ENSMUSP00000147656 Ensembl | MGI Sequence Detail 719 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013468 receptor-type tyrosine-protein phosphatase epsilon
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR050348 Protein-Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      P49446 2 sites
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 57
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13682
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:29004 Yi T, et al., Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Blood. 1991 Nov 1;78(9):2222-8
    • Latest
      J:289159 Cohen-Sharir Y, et al., Protein tyrosine phosphatase alpha inhibits hypothalamic leptin receptor signaling and regulates body weight in vivo. FASEB J. 2019 Apr;33(4):5101-5111
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory