Hcls1 MGI Mouse Gene Detail - MGI:104568 - hematopoietic cell specific Lyn substrate 1

Symbol

Hcls1
Name

hematopoietic cell specific Lyn substrate 1
Synonyms

HS1

Feature Type

protein coding gene
IDs

MGI:104568
NCBI Gene: 15163
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr16:36755345-36783574 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.30 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

708 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104568	protein coding gene	Chr16:36755345-36783576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022796	protein coding gene	Chr16:35357699-35386716 (+)
A/J	MGP_AJ_G0022761	protein coding gene	Chr16:33615786-33643927 (+)
AKR/J	MGP_AKRJ_G0022733	protein coding gene	Chr16:34899331-34928212 (+)
BALB/cJ	MGP_BALBcJ_G0022762	protein coding gene	Chr16:33719364-33747713 (+)
C3H/HeJ	MGP_C3HHeJ_G0022526	protein coding gene	Chr16:35016236-35045937 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023209	protein coding gene	Chr16:36199596-36228683 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020723	protein coding gene	Chr16:33979893-34008215 (+)
CAST/EiJ	MGP_CASTEiJ_G0022052	protein coding gene	Chr16:35137890-35171331 (+)
CBA/J	MGP_CBAJ_G0022497	protein coding gene	Chr16:37778746-37806934 (+)
DBA/2J	MGP_DBA2J_G0022629	protein coding gene	Chr16:33511393-33539493 (+)
FVB/NJ	MGP_FVBNJ_G0022604	protein coding gene	Chr16:33541580-33569729 (+)
LP/J	MGP_LPJ_G0022697	protein coding gene	Chr16:35064604-35091223 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022623	protein coding gene	Chr16:36836043-36868835 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023224	protein coding gene	Chr16:34847571-34876644 (+)
PWK/PhJ	MGP_PWKPhJ_G0021792	protein coding gene	Chr16:33912639-33941311 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021623	protein coding gene	Chr16:34765442-34794630 (+)
WSB/EiJ	MGP_WSBEiJ_G0022096	protein coding gene	Chr16:34904784-34935566 (+)

Human Ortholog

HCLS1, hematopoietic cell-specific Lyn substrate 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HCLS1, hematopoietic cell-specific Lyn substrate 1
Synonyms

CTTNL, HS1, lckBP1, p75
Links

HGNC:4844

NCBI Gene ID: 3059

neXtProt AC: NX_P14317

UniProt: P14317
Chr Location

3q13.33; chr3:121631399-121660927 (-) GRCh38

MGI Vertebrate Homology

Hcls1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HCLS1
Gene Tree

Hcls1

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Phenotype Summary

13 phenotypes from 3 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

6
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene show impaired antibody production to T-independent antigen and impaired proliferative responses of splenic B and T cells after cross-linking of antigen receptors.

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All GO Annotations

60
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

43
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hcls1

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All Sequences

42
RefSeq

2
UniProt

5
CCDS

CCDS37336.1

Ensembl

ENSMUSG00000022831 (Evidence)
NCBI Gene

15163

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022831	Ensembl Gene Model \| MGI Sequence Detail	28230	C57BL/6J	± kb
transcript	ENSMUST00000023531	Ensembl \| MGI Sequence Detail	2016	Not Applicable
polypeptide	ENSMUSP00000023531	Ensembl \| MGI Sequence Detail	486	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008474 hematopoietic lineage cell-specific protein

(term hierarchy)
InterPro Domains

IPR003134 Hs1/Cortactin

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 47

Genomic 4

cDNA 43

Microarray probesets 3

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MGD-MRK-26002, MGI:2146629

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 14
Earliest

J:16376 Fukamachi H, et al., Identification of a protein, SPY75, with repetitive helix-turn-helix motifs and an SH3 domain as a major substrate for protein tyrosine kinase(s) activated by Fc epsilon RI cross-linking. J Immunol. 1994 Jan 15;152(2):642-52
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hcls1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138285	Chr16:36754953-36754956 (+)	-390 bp
Tssr138286	Chr16:36755338-36755375 (+)	12 bp
Tssr138287	Chr16:36755394-36755412 (+)	58 bp
Tssr138288	Chr16:36756408-36756447 (+)	1,083 bp
Tssr138289	Chr16:36761766-36761807 (+)	6,442 bp
Tssr138290	Chr16:36767020-36767033 (+)	11,682 bp
Tssr138291	Chr16:36768390-36768393 (+)	13,047 bp
Tssr138292	Chr16:36768978-36768998 (+)	13,643 bp
Tssr138293	Chr16:36769742-36769747 (+)	14,400 bp
Tssr138294	Chr16:36771498-36771516 (+)	16,162 bp
Tssr138295	Chr16:36771545-36771556 (+)	16,206 bp
Tssr138296	Chr16:36772889-36772903 (+)	17,551 bp
Tssr138297	Chr16:36775043-36775066 (+)	19,710 bp
Tssr138298	Chr16:36775629-36775679 (+)	20,309 bp
Tssr138299	Chr16:36775683-36775694 (+)	20,344 bp
Tssr138300	Chr16:36776337-36776339 (+)	20,993 bp
Tssr138301	Chr16:36782374-36782386 (+)	27,035 bp
Tssr138302	Chr16:36782503-36782516 (+)	27,165 bp
Tssr138303	Chr16:36783046-36783074 (+)	27,715 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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