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Flt3l Gene Detail
Summary
  • Symbol
    Flt3l
  • Name
    FMS-like tyrosine kinase 3 ligand
  • Feature Type
    protein coding gene
  • IDs
    MGI:95560
    NCBI Gene: 14256
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44780607-44785914 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.14 cM, cytoband B2-C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95560
 protein coding gene Chr7:44779212-44785914 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FLT3LG, fms related receptor tyrosine kinase 3 ligand
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLT3LG, fms related receptor tyrosine kinase 3 ligand
  • Synonyms
    FL, FLG3L, FLT3L, IMD125
  • Links
    NCBI Gene ID: 2323
    neXtProt AC: NX_P49771
    UniProt: P49771

  • Chr Location
    19q13.33; chr19:49474207-49486231 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human FLT3LG associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 1 allele in 2 genetic backgrounds
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and healthy but exhibit reduced cellularity in a number of hematopoietic tissues, reduced numbers of myeloid and lymphoid progenitors in the bone marrow, and reduced numbers of dendritic cells and natural killer cells in the lymphoid organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    50
  • cDNA Data
    32
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14256 NCBI Gene Model | MGI Sequence Detail 5308 C57BL/6J ±  kb
    transcript NR_175304 RefSeq | MGI Sequence Detail 1301 ZRU/MplStud  
    polypeptide P49772 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 3
      cDNA 33
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9838
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 98
    • Earliest
      J:16458 Lyman SD, et al., Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Cell. 1993 Dec 17;75(6):1157-67
    • Latest
      J:348742 Momenilandi M, et al., FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. Cell. 2024 May 23;187(11):2817-2837.e31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory