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Rab7 Gene Detail
Summary
  • Symbol
    Rab7
  • Name
    RAB7, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:105068
    NCBI Gene: 19349
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:87976088-88022252 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1234 from dbSNP Build 142
  • Strain Annotations
    17
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105068
 protein coding gene Chr6:87976088-88022252 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031005
 protein coding gene Chr6:89379854-89426631 (-)
A/J MGP_AJ_G0030971
 protein coding gene Chr6:85927700-85975698 (-)
AKR/J MGP_AKRJ_G0030902
 protein coding gene Chr6:88410568-88458876 (-)
BALB/cJ MGP_BALBcJ_G0030984
 protein coding gene Chr6:85929707-85974913 (-)
C3H/HeJ MGP_C3HHeJ_G0030726
 protein coding gene Chr6:95997692-96054806 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031441
 protein coding gene Chr6:91763757-91818603 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030093
 protein coding gene Chr6:88482335-88530187 (-)
CBA/J MGP_CBAJ_G0030668
 protein coding gene Chr6:95317147-95371824 (-)
DBA/2J MGP_DBA2J_G0030824
 protein coding gene Chr6:85221542-85269384 (-)
FVB/NJ MGP_FVBNJ_G0030777
 protein coding gene Chr6:84414728-84461833 (-)
LP/J MGP_LPJ_G0030901
 protein coding gene Chr6:89396541-89453649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030810
 protein coding gene Chr6:99445215-99498349 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031468
 protein coding gene Chr6:88260698-88307752 (-)
PWK/PhJ MGP_PWKPhJ_G0029808
 protein coding gene Chr6:84190281-84236851 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029636
 protein coding gene Chr6:87076994-87124372 (-)
WSB/EiJ MGP_WSBEiJ_G0030174
 protein coding gene Chr6:88710351-88759740 (-)



Homology
more
  • Human Ortholog
    RAB7A, RAB7A, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB7A, RAB7A, member RAS oncogene family
  • Synonyms
    CMT2B, PRO2706, RAB7
  • Links
    NCBI Gene ID: 7879
    neXtProt AC: NX_P51149
    UniProt: P51149

  • Chr Location
    3q21.3; chr3:128693669-128825942 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rab7 mouse models; 1 with human RAB7A associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted alleles exhibit abnormal endocytosis within the visceral endoderm, failure of elongation along the primitive streak and incomplete gastrulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    12
  • cDNA Data
    18
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19349 NCBI Gene Model | MGI Sequence Detail 46165 C57BL/6J ±  kb
    transcript NM_001293652 RefSeq | MGI Sequence Detail 2395 ZRU/MplStud  
    polypeptide P51150 UniProt | EBI | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 19
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32107
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 26
      Diseases 1
      Gene Ontology 33
      Phenotypes 28
    • Earliest
      J:30249 Carroll JM, et al., Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell. 1995 Dec 15;83(6):957-68
    • Latest
      J:354515 Ke J, et al., Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy. Adv Sci (Weinh). 2024 Aug;11(29):e2401676
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory