Mip MGI Mouse Gene Detail - MGI:96990 - major intrinsic protein of lens fiber

Symbol

Mip
Name

major intrinsic protein of lens fiber
Synonyms

Aqp0, aquaporin 0, Cts, lens opacity, Lop, MIP26, shrivelled, Svl

Feature Type

protein coding gene
IDs

MGI:96990
NCBI Gene: 17339
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:128061707-128067681 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.49 cM, cytoband D1
Mapping Data

11 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96990	protein coding gene	Chr10:128061679-128067681 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017852	protein coding gene	Chr10:131935368-131941383 (+)
A/J	MGP_AJ_G0017827	protein coding gene	Chr10:126646244-126652464 (+)
AKR/J	MGP_AKRJ_G0017790	protein coding gene	Chr10:130366575-130374119 (+)
BALB/cJ	MGP_BALBcJ_G0017791	protein coding gene	Chr10:127022883-127029858 (+)
C3H/HeJ	MGP_C3HHeJ_G0017614	protein coding gene	Chr10:130518997-130525005 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018246	protein coding gene	Chr10:136407635-136413609 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015924	protein coding gene	Chr10:120586898-120592839 (+)
CAST/EiJ	MGP_CASTEiJ_G0017175	protein coding gene	Chr10:131231588-131240091 (+)
CBA/J	MGP_CBAJ_G0017584	protein coding gene	Chr10:141944924-141950932 (+)
DBA/2J	MGP_DBA2J_G0017690	protein coding gene	Chr10:125708425-125714399 (+)
FVB/NJ	MGP_FVBNJ_G0017685	protein coding gene	Chr10:124638111-124644086 (+)
LP/J	MGP_LPJ_G0017764	protein coding gene	Chr10:132532004-132538358 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017713	protein coding gene	Chr10:144543038-144549012 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018286	protein coding gene	Chr10:130463334-130469346 (+)
PWK/PhJ	MGP_PWKPhJ_G0016960	protein coding gene	Chr10:125958510-125964916 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016749	protein coding gene	Chr10:129553188-129559245 (+)
WSB/EiJ	MGP_WSBEiJ_G0017234	protein coding gene	Chr10:130676347-130682318 (+)

Human Ortholog

MIP, major intrinsic protein of lens fiber

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIP, major intrinsic protein of lens fiber
Synonyms

AQP0, CTRCT15, LIM1, MIP26, MP26
Links

HGNC:7103

NCBI Gene ID: 4284

neXtProt AC: NX_P30301

UniProt: P30301
Chr Location

12q13.3; chr12:56449502-56469166 (-) GRCh38

MGI Vertebrate Homology

Mip stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MIP
Gene Tree

Mip

Diseases

1 with Mip mouse models; 2 with human MIP associations

Human Disease

Mouse Models

cataract 15 multiple types

IDs

View 7 models

cataract

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

5 with disease annotations

References

4 with disease annotations

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Phenotype Summary

12 phenotypes from 6 alleles in 16 genetic backgrounds
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Endonuclease-mediated

4
Gene trapped

24
Radiation induced

1
Spontaneous

7
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes have microphthalmia and lens opacity. Other defects may include degeneration of lens fiber cells, vacuolization of lens fibers and reduced gamma:alpha crystallin ratio. Heterozygotes have less severe forms of lens cataract and microphthalmia.

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All GO Annotations

35
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

105
cDNA Data

6
Literature Summary

59

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mip

ZFIN mipa, mipb

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS24265.1

Ensembl

ENSMUSG00000025389 (Evidence)
NCBI Gene

17339

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025389	Ensembl Gene Model \| MGI Sequence Detail	5975	C57BL/6J	± kb
transcript	ENSMUST00000026455	Ensembl \| MGI Sequence Detail	2144	Not Applicable
polypeptide	ENSMUSP00000026455	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010911 lens fiber major intrinsic protein

(term hierarchy)
InterPro Domains

IPR023271 Aquaporin-like

IPR034294 Aquaporin transporter

IPR000425 Major intrinsic protein

IPR022357 Major intrinsic protein, conserved site

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All nucleic 18

Genomic 1

cDNA 10

Primer pair 5

Other 2

Microarray probesets 4

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MGD-MRK-10701, MGD-MRK-11842, MGD-MRK-12240, MGD-MRK-14658, MGD-MRK-1767, MGD-MRK-2244, MGI:88560, MGI:96076

Summaries

All 150

Developmental Gene Expression 59

Diseases 4

Gene Ontology 14

Phenotypes 53
Earliest

J:285 PAGET OE, [Hereditary subcapsular cataract; a new dominant allelomorph in house mouse.]. Z Indukt Abstamm Vererbungsl. 1953;85(2):238-44
Latest

J:350084 Zhang L, et al., Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens. Front Genet. 2024;15:1405715

TSS for Mip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96357	Chr10:128061699-128061714 (+)	0 bp
Tssr96358	Chr10:128061812-128061830 (+)	114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24