P2rx1 MGI Mouse Gene Detail - MGI:1098235 - purinergic receptor P2X, ligand-gated ion channel, 1

Symbol

P2rx1
Name

purinergic receptor P2X, ligand-gated ion channel, 1
Synonyms

P2x, P2X1 receptor, Pdcd3, RP-2

Feature Type

protein coding gene
IDs

MGI:1098235
NCBI Gene: 18436
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:72889929-72906026 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.09 cM
Mapping Data

3 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098235	protein coding gene	Chr11:72889882-72906026 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018648	protein coding gene	Chr11:73666373-73682452 (+)
A/J	MGP_AJ_G0018616	protein coding gene	Chr11:70900565-70916653 (+)
AKR/J	MGP_AKRJ_G0018585	protein coding gene	Chr11:73058356-73075634 (+)
BALB/cJ	MGP_BALBcJ_G0018588	protein coding gene	Chr11:71202265-71218327 (+)
C3H/HeJ	MGP_C3HHeJ_G0018401	protein coding gene	Chr11:73022743-73038797 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019039	protein coding gene	Chr11:75886670-75902737 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016682	protein coding gene	Chr11:67711722-67727871 (+)
CAST/EiJ	MGP_CASTEiJ_G0017956	protein coding gene	Chr11:73400130-73417655 (+)
CBA/J	MGP_CBAJ_G0018373	protein coding gene	Chr11:79257709-79273770 (+)
DBA/2J	MGP_DBA2J_G0018482	protein coding gene	Chr11:70530715-70546753 (+)
FVB/NJ	MGP_FVBNJ_G0018473	protein coding gene	Chr11:70075193-70091558 (+)
LP/J	MGP_LPJ_G0018553	protein coding gene	Chr11:74160543-74176668 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018496	protein coding gene	Chr11:79781413-79797472 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019081	protein coding gene	Chr11:73257372-73273436 (+)
PWK/PhJ	MGP_PWKPhJ_G0017729	protein coding gene	Chr11:71167004-71183126 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017519	protein coding gene	Chr11:72965309-72982461 (+)
WSB/EiJ	MGP_WSBEiJ_G0018010	protein coding gene	Chr11:72998854-73015836 (+)

Human Ortholog

P2RX1, purinergic receptor P2X 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

P2RX1, purinergic receptor P2X 1
Synonyms

P2X1
Links

HGNC:8533

NCBI Gene ID: 5023

neXtProt AC: NX_P51575

UniProt: P51575
Chr Location

17p13.2; chr17:3896592-3916476 (-) GRCh38

MGI Vertebrate Homology

P2rx1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: P2RX1
Protein SuperFamily

P2X_purinoceptor
Gene Tree

P2rx1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

5
Genomic Mutations

2 involving P2rx1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit low male fertility due to impaired vas deferens contraction and reduced numbers of ejaculated sperm. Mutants also show mild hypertension and reduced susceptibility to experimental thromboembolism.

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All GO Annotations

74
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

822
Tissues

49
cDNA Data

20
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase p2rx1

ZFIN p2rx1

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS24992.1

Ensembl

ENSMUSG00000020787 (Evidence)
NCBI Gene

18436

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020787	Ensembl Gene Model \| MGI Sequence Detail	16098	C57BL/6J	± kb
transcript	ENSMUST00000021141	Ensembl \| MGI Sequence Detail	2486	Not Applicable
polypeptide	ENSMUSP00000021141	Ensembl \| MGI Sequence Detail	399	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012188 P2X purinoceptor 1

(term hierarchy)
InterPro Domains

IPR003044 P2X1 purinoceptor

IPR001429 P2X purinoreceptor

IPR027309 P2X purinoreceptor extracellular domain superfamily
GlyGen

P51576 5 sites, 3 N-linked glycans (3 sites)

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All nucleic 23

Genomic 1

cDNA 20

Primer pair 2

Microarray probesets 5

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MGD-MRK-32146, MGI:105106, MGI:2144121, MGI:2144602

Summaries

All 74

Developmental Gene Expression 7

Gene Ontology 16

Phenotypes 25
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:307850 Illes P, et al., Update of P2X receptor properties and their pharmacology: IUPHAR Review 30. Br J Pharmacol. 2021 Feb;178(3):489-514

TSS for P2rx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102868	Chr11:72889895-72889918 (+)	-22 bp
Tssr102869	Chr11:72889954-72889963 (+)	30 bp
Tssr102870	Chr11:72899930-72899943 (+)	10,008 bp
Tssr102871	Chr11:72900506-72900517 (+)	10,583 bp
Tssr102872	Chr11:72900546-72900563 (+)	10,626 bp
Tssr102873	Chr11:72900575-72900624 (+)	10,671 bp
Tssr102874	Chr11:72900626-72900646 (+)	10,707 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24