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Adcy7 Gene Detail
Summary
  • Symbol
    Adcy7
  • Name
    adenylate cyclase 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:102891
    NCBI Gene: 11513
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:88999031-89056590 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.06 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1667 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102891
 protein coding gene Chr8:88998818-89056593 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033918
 protein coding gene Chr8:89349241-89409137 (+)
A/J MGP_AJ_G0033901
 protein coding gene Chr8:85832383-85890741 (+)
AKR/J MGP_AKRJ_G0033827
 protein coding gene Chr8:88353690-88416875 (+)
BALB/cJ MGP_BALBcJ_G0033894
 protein coding gene Chr8:85991606-86052141 (+)
C3H/HeJ MGP_C3HHeJ_G0033604
 protein coding gene Chr8:88959124-89017718 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034414
 protein coding gene Chr8:92713550-92777689 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031356
 protein coding gene Chr8:79811023-79867776 (+)
CAST/EiJ MGP_CASTEiJ_G0032935
 protein coding gene Chr8:88392024-88454011 (+)
CBA/J MGP_CBAJ_G0033580
 protein coding gene Chr8:95856579-95924039 (+)
DBA/2J MGP_DBA2J_G0033733
 protein coding gene Chr8:85421157-85480164 (+)
FVB/NJ MGP_FVBNJ_G0033680
 protein coding gene Chr8:84379002-84439874 (+)
LP/J MGP_LPJ_G0033825
 protein coding gene Chr8:89460233-89523654 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033723
 protein coding gene Chr8:98322183-98383259 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034433
 protein coding gene Chr8:88365764-88427952 (+)
PWK/PhJ MGP_PWKPhJ_G0032638
 protein coding gene Chr8:84692111-84750330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032474
 protein coding gene Chr8:87176941-87234631 (+)
WSB/EiJ MGP_WSBEiJ_G0033046
 protein coding gene Chr8:88807130-88871329 (+)



Homology
more
  • Human Ortholog
    ADCY7, adenylate cyclase 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADCY7, adenylate cyclase 7
  • Synonyms
    AC7
  • Links
    NCBI Gene ID: 113
    neXtProt AC: NX_P51828
    UniProt: P51828

  • Chr Location
    16q12.1; chr16:50244699-50318135 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display some degree of pre- or postnatal lethality. Surviving adults for one allele appear to be normal. Heterozygous females for one allele display decreased depression related behaviors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1039
  • Tissues
    168
  • cDNA Data
    18
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031659 Ensembl Gene Model | MGI Sequence Detail 57560 C57BL/6J ±  kb
transcript ENSMUST00000098521 Ensembl | MGI Sequence Detail 5937 Not Applicable  
polypeptide ENSMUSP00000096122 Ensembl | MGI Sequence Detail 1099 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 20
    Primer pair 2
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-23725, MGI:2142399
References
more
  • Summaries
    All 79
    Developmental Gene Expression 12
    Gene Ontology 13
    Phenotypes 41
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:350533 Li G, et al., Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2315282120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory