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Matn1 Gene Detail
Summary
  • Symbol
    Matn1
  • Name
    matrilin 1, cartilage matrix protein
  • Synonyms
    CMP, Crtm, Mat1, matrilin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:106591
    NCBI Gene: 17180
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130671696-130682786 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106591
 protein coding gene Chr4:130671696-130682787 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028856
 protein coding gene Chr4:132998107-133008229 (+)
A/J MGP_AJ_G0028815
 protein coding gene Chr4:127480188-127490613 (+)
AKR/J MGP_AKRJ_G0028768
 protein coding gene Chr4:131062882-131074355 (+)
BALB/cJ MGP_BALBcJ_G0028838
 protein coding gene Chr4:128096022-128106060 (+)
C3H/HeJ MGP_C3HHeJ_G0028552
 protein coding gene Chr4:131290347-131300882 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029280
 protein coding gene Chr4:137800142-137809501 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026552
 protein coding gene Chr4:120580182-120589432 (+)
CAST/EiJ MGP_CASTEiJ_G0027985
 protein coding gene Chr4:129341720-129356220 (+)
CBA/J MGP_CBAJ_G0028518
 protein coding gene Chr4:141319242-141334284 (+)
DBA/2J MGP_DBA2J_G0028667
 protein coding gene Chr4:127913114-127922507 (+)
FVB/NJ MGP_FVBNJ_G0028634
 protein coding gene Chr4:126738847-126748257 (+)
LP/J MGP_LPJ_G0028768
 protein coding gene Chr4:133154220-133165803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028660
 protein coding gene Chr4:146000410-146009828 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029318
 protein coding gene Chr4:131437963-131447410 (+)
PWK/PhJ MGP_PWKPhJ_G0027706
 protein coding gene Chr4:124553603-124564303 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027532
 protein coding gene Chr4:127298220-127307498 (+)
WSB/EiJ MGP_WSBEiJ_G0028065
 protein coding gene Chr4:131594516-131604853 (+)



Homology
more
  • Human Ortholog
    MATN1, matrilin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATN1, matrilin 1
  • Synonyms
    CMP, CRTM
  • Links
    NCBI Gene ID: 4146
    neXtProt AC: NX_P21941
    UniProt: P21941

  • Chr Location
    1p35.2; chr1:30711277-30723585 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are viable, fertile and display normal cartilage development and endochondral bone formation. Mice homozygous for one targeted allele show alterations in type II collagen fibrillogenesis and fibril organization, in the absence of skeletal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1078
  • Tissues
    98
  • cDNA Data
    23
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040533 Ensembl Gene Model | MGI Sequence Detail 11091 C57BL/6J ±  kb
    transcript ENSMUST00000102576 Ensembl | MGI Sequence Detail 2001 Not Applicable  
    polypeptide ENSMUSP00000099636 Ensembl | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 23
      Primer pair 8
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-35047
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 37
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:320146 Winterbottom N, et al., Cartilage matrix protein is a component of the collagen fibril of cartilage. Dev Dyn. 1992 Mar;193(3):266-76
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory