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Ccna2 Gene Detail
Summary
  • Symbol
    Ccna2
  • Name
    cyclin A2
  • Synonyms
    Ccn-1, Ccn1, Ccna, Cyca, CycA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108069
    NCBI Gene: 12428
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:36619014-36626299 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 17.67 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108069
 protein coding gene Chr3:36619014-36627187 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027161
 protein coding gene Chr3:34368175-34375409 (-)
A/J MGP_AJ_G0027121
 protein coding gene Chr3:33712750-33719984 (-)
AKR/J MGP_AKRJ_G0027090
 protein coding gene Chr3:34333850-34341139 (-)
BALB/cJ MGP_BALBcJ_G0027133
 protein coding gene Chr3:33469455-33476740 (-)
C3H/HeJ MGP_C3HHeJ_G0026876
 protein coding gene Chr3:34393383-34400617 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027579
 protein coding gene Chr3:36013634-36020919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024940
 protein coding gene Chr3:31411781-31419034 (-)
CAST/EiJ MGP_CASTEiJ_G0026329
 protein coding gene Chr3:34242153-34249430 (-)
CBA/J MGP_CBAJ_G0026853
 protein coding gene Chr3:36993127-37000361 (-)
DBA/2J MGP_DBA2J_G0026987
 protein coding gene Chr3:33166615-33173849 (-)
FVB/NJ MGP_FVBNJ_G0026955
 protein coding gene Chr3:32617679-32624964 (-)
LP/J MGP_LPJ_G0027099
 protein coding gene Chr3:35151192-35158426 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026975
 protein coding gene Chr3:39407637-39414880 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027638
 protein coding gene Chr3:34169968-34177205 (-)
PWK/PhJ MGP_PWKPhJ_G0026062
 protein coding gene Chr3:32814243-32821529 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025874
 protein coding gene Chr3:33549253-33556557 (-)
WSB/EiJ MGP_WSBEiJ_G0026403
 protein coding gene Chr3:34195674-34202911 (-)



Homology
more
  • Human Ortholog
    CCNA2, cyclin A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCNA2, cyclin A2
  • Synonyms
    CCN1, CCNA
  • Links
    NCBI Gene ID: 890
    neXtProt AC: NX_P20248
    UniProt: P20248

  • Chr Location
    4q27; chr4:121816444-121823883 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted mutation implant in the uterine wall, but fail to develop past 5.5 dpc. Notably, mutant embryos develop normally from the four-cell to the post-implantation stage in the absence of detectable maternally-derived gene products.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1085
  • Tissues
    206
  • cDNA Data
    16
  • Literature Summary
    124
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027715 Ensembl Gene Model | MGI Sequence Detail 7286 C57BL/6J ±  kb
    transcript ENSMUST00000029270 Ensembl | MGI Sequence Detail 2965 Not Applicable  
    polypeptide ENSMUSP00000029270 Ensembl | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 1
      cDNA 17
      Primer pair 21
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1805, MGD-MRK-1807, MGD-MRK-1809, MGD-MRK-2264, MGD-MRK-37106, MGI:2139562
    References
    more
    • Summaries
      All 216
      Developmental Gene Expression 124
      Diseases 1
      Gene Ontology 16
      Phenotypes 29
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:349860 Hashimoto K, et al., Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics. Sci Rep. 2024 Jun 14;14(1):13727
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/22/2024
    MGI 6.24     		The Jackson Laboratory