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Pold1 Gene Detail
Summary
  • Symbol
    Pold1
  • Name
    polymerase (DNA directed), delta 1, catalytic subunit
  • Synonyms
    125kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:97741
    NCBI Gene: 18971
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44182168-44198239 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    453 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97741
 protein coding gene Chr7:44182168-44198273 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032168
 protein coding gene Chr7:44707778-44725573 (-)
A/J MGP_AJ_G0032147
 protein coding gene Chr7:43889924-43905988 (-)
AKR/J MGP_AKRJ_G0032083
 protein coding gene Chr7:45095440-45111308 (-)
BALB/cJ MGP_BALBcJ_G0032159
 protein coding gene Chr7:43885956-43903517 (-)
C3H/HeJ MGP_C3HHeJ_G0031875
 protein coding gene Chr7:45585886-45601613 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032651
 protein coding gene Chr7:46967155-46984931 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029665
 protein coding gene Chr7:46475302-46490985 (-)
CAST/EiJ MGP_CASTEiJ_G0031203
 protein coding gene Chr7:36969314-36984981 (-)
CBA/J MGP_CBAJ_G0031839
 protein coding gene Chr7:48508765-48524633 (-)
DBA/2J MGP_DBA2J_G0031997
 protein coding gene Chr7:43563960-43579891 (-)
FVB/NJ MGP_FVBNJ_G0031948
 protein coding gene Chr7:43304876-43323266 (-)
LP/J MGP_LPJ_G0032075
 protein coding gene Chr7:45393797-45409856 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031985
 protein coding gene Chr7:47243554-47259418 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032667
 protein coding gene Chr7:44316130-44332190 (-)
PWK/PhJ MGP_PWKPhJ_G0030926
 protein coding gene Chr7:36912774-36928470 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030763
 protein coding gene Chr7:32319237-32337537 (-)
WSB/EiJ MGP_WSBEiJ_G0031320
 protein coding gene Chr7:44772494-44789275 (-)



Homology
more
  • Human Ortholog
    POLD1, DNA polymerase delta 1, catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLD1, DNA polymerase delta 1, catalytic subunit
  • Synonyms
    CDC2, CRCS10, IMD120, MDPL, POLD
  • Links
    NCBI Gene ID: 5424
    neXtProt AC: NX_P28340
    UniProt: P28340

  • Chr Location
    19q13.33; chr19:50384204-50418018 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 8 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    4 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have an elevated mutation rate as well as an increased incidence of tumors. Median age for these mice is around 10 months.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    855
  • Tissues
    121
  • cDNA Data
    118
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18971 NCBI Gene Model | MGI Sequence Detail 16072 C57BL/6J ±  kb
    transcript NM_011131 RefSeq | MGI Sequence Detail 3428 ZRU/MplStud  
    polypeptide P52431 UniProt | EBI | MGI Sequence Detail 1105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 1
      cDNA 118
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13579
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 20
    • Earliest
      J:16041 Cullmann G, et al., Cloning of a mouse cDNA encoding DNA polymerase delta: refinement of the homology boxes. Gene. 1993 Dec 8;134(2):191-200
    • Latest
      J:327432 Chen T, et al., A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open. 2022 Aug 15;11(8):bio059307
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory