Upp1 MGI Mouse Gene Detail - MGI:1097668

Symbol

Upp1
Name

uridine phosphorylase 1
Synonyms

UdRPase, Up, UPase

Feature Type

protein coding gene
IDs

MGI:1097668
NCBI Gene: 22271
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:9068103-9086170 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 6.13 cM, cytoband A1-2
Mapping Data

2 experiments

SNPs within 2kb

567 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1097668	protein coding gene	Chr11:9068008-9086170 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018040	protein coding gene	Chr11:6358768-6380285 (+)
A/J	MGP_AJ_G0018013	protein coding gene	Chr11:6089824-6107656 (+)
AKR/J	MGP_AKRJ_G0017977	protein coding gene	Chr11:6308386-6328005 (+)
BALB/cJ	MGP_BALBcJ_G0017981	protein coding gene	Chr11:6078506-6096661 (+)
C3H/HeJ	MGP_C3HHeJ_G0017794	protein coding gene	Chr11:6225836-6244880 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018433	protein coding gene	Chr11:6519727-6538734 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016091	protein coding gene	Chr11:5813931-5831762 (+)
CAST/EiJ	MGP_CASTEiJ_G0017356	protein coding gene	Chr11:6252852-6274864 (+)
CBA/J	MGP_CBAJ_G0017769	protein coding gene	Chr11:7076665-7097240 (+)
DBA/2J	MGP_DBA2J_G0017879	protein coding gene	Chr11:6047383-6065583 (+)
FVB/NJ	MGP_FVBNJ_G0017871	protein coding gene	Chr11:5993898-6013894 (+)
LP/J	MGP_LPJ_G0017950	protein coding gene	Chr11:6386245-6404816 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017897	protein coding gene	Chr11:6623233-6642087 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018473	protein coding gene	Chr11:6442100-6462370 (+)
PWK/PhJ	MGP_PWKPhJ_G0017136	protein coding gene	Chr11:6026085-6043801 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016933	protein coding gene	Chr11:6279466-6297141 (+)
WSB/EiJ	MGP_WSBEiJ_G0017410	protein coding gene	Chr11:6188070-6209087 (+)

Human Ortholog

UPP1, uridine phosphorylase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UPP1, uridine phosphorylase 1
Synonyms

UDRPASE, UP, UPASE, UPP
Links

HGNC:12576

NCBI Gene ID: 7378

neXtProt AC: NX_Q16831

UniProt: Q16831
Chr Location

7p12.3; chr7:48088628-48108736 (+) GRCh38

MGI Vertebrate Homology

Upp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UPP1
Gene Tree

Upp1

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Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
13 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

94
Endonuclease-mediated

2
Gene trapped

86
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted disruption have increased uridine concentration in tissues, urine and blood, along with disorders of various nucleotide metabolisms and decreased sensitivity to pentobarbital and 5-fluorouracil.

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All GO Annotations

27
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

98
cDNA Data

37
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase upp1

ZFIN upp1

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All Sequences

61
RefSeq

8
UniProt

6
CCDS

CCDS24432.1

Ensembl

ENSMUSG00000020407 (Evidence)
NCBI Gene

22271

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020407	Ensembl Gene Model \| MGI Sequence Detail	18068	C57BL/6J	± kb
transcript	ENSMUST00000020677	Ensembl \| MGI Sequence Detail	1277	Not Applicable
polypeptide	ENSMUSP00000020677	Ensembl \| MGI Sequence Detail	311	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017117 uridine phosphorylase 1

(term hierarchy)
EC

2.4.2.3
InterPro Domains

IPR018016 Nucleoside phosphorylase, conserved site

IPR000845 Nucleoside phosphorylase domain

IPR035994 Nucleoside phosphorylase superfamily

IPR010059 Uridine phosphorylase, eukaryotic

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All nucleic 41

Genomic 1

cDNA 37

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2144130

Summaries

All 59

Developmental Gene Expression 8

Diseases 2

Gene Ontology 12

Phenotypes 24
Earliest

J:297468 KRENITSKY TA, et al., SPECIFICITY OF MOUSE URIDINE PHOSPHORYLASE. CHROMATOGRAPHY, PURIFICATION, AND PROPERTIES. J Biol Chem. 1964 Mar;239:805-12
Latest

J:347415 Zocher S, et al., Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024 Apr 5;384(6691):53-59

TSS for Upp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100322	Chr11:9067952-9067990 (+)	-132 bp
Tssr100323	Chr11:9067998-9068017 (+)	-95 bp
Tssr100324	Chr11:9068070-9068091 (+)	-22 bp
Tssr3423	Chr11:9068098-9068133 (+)	13 bp
Tssr3424	Chr11:9068134-9068141 (+)	35 bp
Tssr100325	Chr11:9068536-9068556 (+)	443 bp
Tssr100326	Chr11:9068571-9068593 (+)	479 bp
Tssr100327	Chr11:9068619-9068634 (+)	524 bp
Tssr100328	Chr11:9069223-9069230 (+)	1,124 bp
Tssr100329	Chr11:9069279-9069296 (+)	1,185 bp
Tssr100330	Chr11:9070056-9070064 (+)	1,957 bp
Tssr100331	Chr11:9075114-9075143 (+)	7,026 bp
Tssr100332	Chr11:9075157-9075170 (+)	7,061 bp
Tssr100333	Chr11:9081624-9081631 (+)	13,525 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24