Stat6 MGI Mouse Gene Detail - MGI:103034 - signal transducer and activator of transcription 6

Symbol

Stat6
Name

signal transducer and activator of transcription 6

Feature Type

protein coding gene
IDs

MGI:103034
NCBI Gene: 20852
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:127478855-127496826 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.59 cM
Mapping Data

5 experiments

SNPs within 2kb

460 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103034	protein coding gene	Chr10:127478855-127496856 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017828	protein coding gene	Chr10:131268808-131286650 (+)
A/J	MGP_AJ_G0017803	protein coding gene	Chr10:126013804-126031952 (+)
AKR/J	MGP_AKRJ_G0017766	protein coding gene	Chr10:129733801-129751603 (+)
BALB/cJ	MGP_BALBcJ_G0017767	protein coding gene	Chr10:126415177-126434182 (+)
C3H/HeJ	MGP_C3HHeJ_G0017591	protein coding gene	Chr10:129885484-129906644 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018222	protein coding gene	Chr10:135714923-135734568 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015902	protein coding gene	Chr10:119997916-120015832 (+)
CAST/EiJ	MGP_CASTEiJ_G0017151	protein coding gene	Chr10:130548409-130570989 (+)
CBA/J	MGP_CBAJ_G0017560	protein coding gene	Chr10:141187108-141208523 (+)
DBA/2J	MGP_DBA2J_G0017666	protein coding gene	Chr10:125088534-125106621 (+)
FVB/NJ	MGP_FVBNJ_G0017661	protein coding gene	Chr10:124030356-124048995 (+)
LP/J	MGP_LPJ_G0017740	protein coding gene	Chr10:131843251-131861447 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017689	protein coding gene	Chr10:143870833-143888819 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018262	protein coding gene	Chr10:129805779-129825825 (+)
PWK/PhJ	MGP_PWKPhJ_G0016936	protein coding gene	Chr10:125294810-125314308 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016728	protein coding gene	Chr10:128834439-128857409 (+)
WSB/EiJ	MGP_WSBEiJ_G0017212	protein coding gene	Chr10:130025630-130048191 (+)

Human Ortholog

STAT6, signal transducer and activator of transcription 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STAT6, signal transducer and activator of transcription 6
Synonyms

D12S1644, HIES6, IL-4-STAT, STAT6B, STAT6C
Links

HGNC:11368

NCBI Gene ID: 6778

neXtProt AC: NX_P42226

UniProt: P42226
Chr Location

12q13.3; chr12:57095408-57132139 (-) GRCh38

MGI Vertebrate Homology

Stat6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STAT6
Gene Tree

Stat6

Diseases

5 with human STAT6 associations

				Human Disease	Mouse Models
				colon adenocarcinoma IDs colon adenocarcinoma DOID:234 MESH:D003110 NCI:C4349 UMLS_CUI:C0338106
				lipoid nephrosis IDs lipoid nephrosis DOID:10966 ICD10CM:N04 ICD9CM_2006:581.3 MESH:D009402 NCI:C34844 UMLS_CUI:C0027721
				prostate carcinoma IDs prostate carcinoma DOID:10286 EFO:0001663 KEGG:05215 NCI:C4863 UMLS_CUI:C0600139
				rectum adenocarcinoma IDs rectum adenocarcinoma DOID:1996 NCI:C9383 UMLS_CUI:C0149978
				urinary schistosomiasis IDs urinary schistosomiasis DOID:1394 ICD9CM:120.0 ICD9CM_2006:120.0 MESH:D012553 NCI:C39294 UMLS_CUI:C0276926

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

70 phenotypes from 3 alleles in 10 genetic backgrounds
42 phenotypes from multigenic genotypes
496 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

6
Gene trapped

6
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit impaired IL4 responses, including anti-IgM stimulated B cell proliferation, class switching to IgE, contact sensitivity, and Th2 cytokine production, and show increased resistance to certain infections.

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All GO Annotations

67
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

57
cDNA Data

78
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stat6

ZFIN stat6

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All Sequences

49
RefSeq

2
UniProt

4
CCDS

CCDS36082.1

Ensembl

ENSMUSG00000002147 (Evidence)
NCBI Gene

20852

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002147	Ensembl Gene Model \| MGI Sequence Detail	17972	C57BL/6J	± kb
transcript	ENSMUST00000092074	Ensembl \| MGI Sequence Detail	3775	Not Applicable
polypeptide	ENSMUSP00000089708	Ensembl \| MGI Sequence Detail	837	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000002093 signal transducer and activator of transcription 6

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR048988 Signal transducer and activator of transcription, linker domain

IPR028187 STAT6, C-terminal

IPR035857 STAT6, SH2 domain

IPR013800 STAT transcription factor, all-alpha domain

IPR015988 STAT transcription factor, coiled coil

IPR013801 STAT transcription factor, DNA-binding

IPR012345 STAT transcription factor, DNA-binding, N-terminal

IPR036535 STAT transcription factor, N-terminal domain superfamily

IPR013799 STAT transcription factor, protein interaction

IPR001217 Transcription factor STAT
GlyGen

P52633 9 sites, 1 O-linked glycan (9 sites)

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All nucleic 83

Genomic 2

cDNA 78

Primer pair 3

Microarray probesets 4

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MGD-MRK-23872

Summaries

All 634

Developmental Gene Expression 14

Gene Ontology 23

Phenotypes 496
Earliest

J:29554 Hou J, et al., An interleukin-4-induced transcription factor: IL-4 Stat. Science. 1994 Sep 16;265(5179):1701-6
Latest

J:353755 Farrokhi A, et al., Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia. Blood. 2024 Aug 22;144(8):809-821

TSS for Stat6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96230	Chr10:127478844-127478903 (+)	19 bp
Tssr96231	Chr10:127478904-127478913 (+)	54 bp
Tssr96232	Chr10:127478954-127478973 (+)	109 bp
Tssr96233	Chr10:127478983-127478990 (+)	132 bp
Tssr96234	Chr10:127479011-127479027 (+)	164 bp
Tssr96235	Chr10:127479043-127479054 (+)	194 bp
Tssr96236	Chr10:127494090-127494098 (+)	15,239 bp
Tssr96237	Chr10:127494193-127494200 (+)	15,342 bp
Tssr96238	Chr10:127494220-127494253 (+)	15,382 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24