Tia1 MGI Mouse Gene Detail - MGI:107914 - cytotoxic granule-associated RNA binding protein 1

Symbol

Tia1
Name

cytotoxic granule-associated RNA binding protein 1
Synonyms

2310050N03Rik, mTIA-1

Feature Type

protein coding gene
IDs

MGI:107914
NCBI Gene: 21841
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:86381201-86410387 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.69 cM, cytoband D2
Mapping Data

4 experiments

SNPs within 2kb

660 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107914	protein coding gene	Chr6:86381001-86410387 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030975	protein coding gene	Chr6:87685450-87717222 (+)
A/J	MGP_AJ_G0030941	protein coding gene	Chr6:84303542-84333903 (+)
AKR/J	MGP_AKRJ_G0030872	protein coding gene	Chr6:86742612-86778346 (+)
BALB/cJ	MGP_BALBcJ_G0030954	protein coding gene	Chr6:84314384-84343672 (+)
C3H/HeJ	MGP_C3HHeJ_G0030756	protein coding gene	Chr6:97685377-97714431 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031411	protein coding gene	Chr6:90066103-90100604 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028595	protein coding gene	Chr6:82479949-82510306 (+)
CAST/EiJ	MGP_CASTEiJ_G0030063	protein coding gene	Chr6:86815111-86845518 (+)
CBA/J	MGP_CBAJ_G0030638	protein coding gene	Chr6:93606187-93644330 (+)
DBA/2J	MGP_DBA2J_G0030794	protein coding gene	Chr6:83621125-83652095 (+)
FVB/NJ	MGP_FVBNJ_G0030747	protein coding gene	Chr6:82805769-82834994 (+)
LP/J	MGP_LPJ_G0030871	protein coding gene	Chr6:87720168-87756885 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030780	protein coding gene	Chr6:97740620-97772931 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031438	protein coding gene	Chr6:86592367-86621521 (+)
PWK/PhJ	MGP_PWKPhJ_G0029778	protein coding gene	Chr6:82564356-82593971 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029606	protein coding gene	Chr6:85427097-85458023 (+)
WSB/EiJ	MGP_WSBEiJ_G0030144	protein coding gene	Chr6:87042041-87072599 (+)

Human Ortholog

TIA1, TIA1 cytotoxic granule associated RNA binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TIA1, TIA1 cytotoxic granule associated RNA binding protein
Synonyms

ALS26, TIA-1, WDM
Links

HGNC:11802

NCBI Gene ID: 7072

neXtProt AC: NX_P31483

UniProt: P31483
Chr Location

2p13.3; chr2:70209444-70248793 (-) GRCh38

MGI Vertebrate Homology

Tia1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TIA1
Gene Tree

Tia1

Diseases

1 with human TIA1 associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis type 26 IDs amyotrophic lateral sclerosis type 26 DOID:0081380 OMIM:619133

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Endonuclease-mediated

3
Gene trapped

27
Spontaneous

1
Targeted

7
Genomic Mutations

1 involving Tia1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit reduced postnatal survival and functional abnormalities in the immune system with no gross abnormalities in any of the major organs.

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All GO Annotations

34
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

899
Tissues

130
cDNA Data

167
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tia1

ZFIN tia1

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All Sequences

135
RefSeq

36
UniProt

11
CCDS

CCDS20312.1, CCDS51833.1, CCDS51834.1

Ensembl

ENSMUSG00000071337 (Evidence)
NCBI Gene

21841

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071337	Ensembl Gene Model \| MGI Sequence Detail	29187	C57BL/6J	± kb
transcript	ENSMUST00000095753	Ensembl \| MGI Sequence Detail	4477	Not Applicable
polypeptide	ENSMUSP00000093425	Ensembl \| MGI Sequence Detail	386	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000029793 cytotoxic granule associated RNA binding protein TIA1

(term hierarchy)
PDB

2DGO, 2RNE
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote

IPR034827 TIA-1, RNA recognition motif 1

IPR034830 TIA-1, RNA recognition motif 2

IPR034496 TIAR, RNA recognition motif 3

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All nucleic 178

Genomic 3

cDNA 173

Primer pair 2

Microarray probesets 9

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MGD-MRK-36494, MGI:1889799, MGI:1914358

Summaries

All 92

Developmental Gene Expression 12

Gene Ontology 16

Phenotypes 31
Earliest

J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tia1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57463	Chr6:86381173-86381180 (+)	-24 bp
Tssr57464	Chr6:86381202-86381222 (+)	11 bp
Tssr57465	Chr6:86381239-86381301 (+)	69 bp
Tssr57466	Chr6:86381323-86381362 (+)	142 bp
Tssr57467	Chr6:86382859-86382864 (+)	1,661 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24