Lbx1 MGI Mouse Gene Detail - MGI:104867

Symbol

Lbx1
Name

ladybird homeobox 1
Synonyms

Lbx1h

Feature Type

protein coding gene
IDs

MGI:104867
NCBI Gene: 16814
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:45221123-45224251 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.61 cM, cytoband D
Mapping Data

1 experiment

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104867	protein coding gene	Chr19:45221123-45225280 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025186	protein coding gene	Chr19:44793139-44796270 (-)
A/J	MGP_AJ_G0025163	protein coding gene	Chr19:42621375-42624504 (-)
AKR/J	MGP_AKRJ_G0025131	protein coding gene	Chr19:43996826-43999957 (-)
BALB/cJ	MGP_BALBcJ_G0025157	protein coding gene	Chr19:42673130-42676259 (-)
C3H/HeJ	MGP_C3HHeJ_G0024917	protein coding gene	Chr19:44178230-44181362 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025600	protein coding gene	Chr19:45918184-45921312 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023014	protein coding gene	Chr19:41885964-41889093 (-)
CAST/EiJ	MGP_CASTEiJ_G0024382	protein coding gene	Chr19:43904848-43908007 (-)
CBA/J	MGP_CBAJ_G0024897	protein coding gene	Chr19:48221092-48224224 (-)
DBA/2J	MGP_DBA2J_G0025029	protein coding gene	Chr19:42441569-42444698 (-)
FVB/NJ	MGP_FVBNJ_G0024990	protein coding gene	Chr19:42213842-42216970 (-)
LP/J	MGP_LPJ_G0025115	protein coding gene	Chr19:44727648-44730815 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025021	protein coding gene	Chr19:47579744-47582880 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025658	protein coding gene	Chr19:44072018-44075148 (-)
PWK/PhJ	MGP_PWKPhJ_G0024130	protein coding gene	Chr19:42262005-42265139 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023935	protein coding gene	Chr19:42755443-42758581 (-)
WSB/EiJ	MGP_WSBEiJ_G0024452	protein coding gene	Chr19:44228229-44231357 (-)

Human Ortholog

LBX1, ladybird homeobox 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LBX1, ladybird homeobox 1
Synonyms

CCHS3, homeobox, HPX-6, HPX6, LBX1H
Links

HGNC:16960

NCBI Gene ID: 10660

neXtProt AC: NX_P52954

UniProt: P52954
Chr Location

10q24.32; chr10:101226994-101229463 (-) GRCh38

MGI Vertebrate Homology

Lbx1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LBX1
Gene Tree

Lbx1

Diseases

1 with human LBX1 associations

				Human Disease	Mouse Models
				congenital central hypoventilation syndrome IDs congenital central hypoventilation syndrome DOID:0060731 ICD10CM:G47.3 MESH:C536209 OMIM:209880 ORDO:661

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

41 phenotypes from 5 alleles in 9 genetic backgrounds
9 phenotypes from multigenic genotypes
68 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Targeted

14
Genomic Mutations

3 involving Lbx1
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice display impaired limb muscle development resulting from progenitor cell migration defects. Defects in heart development and nervous system morphology are also reported.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

985
Tissues

137
cDNA Data

10
Literature Summary

116

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lbx1

ZFIN lbx1a, lbx1b

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS29859.1

Ensembl

ENSMUSG00000025216 (Evidence)
NCBI Gene

16814

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025216	Ensembl Gene Model \| MGI Sequence Detail	3129	C57BL/6J	± kb
transcript	ENSMUST00000099401	Ensembl \| MGI Sequence Detail	2484	Not Applicable
polypeptide	ENSMUSP00000096997	Ensembl \| MGI Sequence Detail	282	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009693 transcription factor LBX1

(term hierarchy)
InterPro Domains

IPR000047 Helix-turn-helix motif

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR051892 LBX Family Transcription Factors

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All nucleic 23

Genomic 8

cDNA 11

Primer pair 2

Other 2

Microarray probesets 3

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MGD-MRK-28164

Summaries

All 185

Developmental Gene Expression 116

Gene Ontology 10

Phenotypes 68
Earliest

J:29933 Jagla K, et al., Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995 Nov;53(3):345-56
Latest

J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;

TSS for Lbx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159549	Chr19:45225266-45225311 (-)	-1,038 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24