Ephb2 MGI Mouse Gene Detail - MGI:99611

Symbol

Ephb2
Name

Eph receptor B2
Synonyms

Cek5, Drt, Erk, eteck, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5

Feature Type

protein coding gene
IDs

MGI:99611
NCBI Gene: 13844
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:136374850-136563299 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 69.00 cM, cytoband D-E
Mapping Data

9 experiments

SNPs within 2kb

5303 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99611	protein coding gene	Chr4:136374850-136563637 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028972	protein coding gene	Chr4:139231649-139426440 (-)
A/J	MGP_AJ_G0028931	protein coding gene	Chr4:133301651-133493607 (-)
AKR/J	MGP_AKRJ_G0028883	protein coding gene	Chr4:137140564-137335903 (-)
BALB/cJ	MGP_BALBcJ_G0028955	protein coding gene	Chr4:133957457-134151205 (-)
C3H/HeJ	MGP_C3HHeJ_G0028669	protein coding gene	Chr4:137427292-137626384 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029396	protein coding gene	Chr4:144201636-144396884 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026667	protein coding gene	Chr4:126327478-126522034 (-)
CAST/EiJ	MGP_CASTEiJ_G0028101	protein coding gene	Chr4:135589220-135784547 (-)
CBA/J	MGP_CBAJ_G0028634	protein coding gene	Chr4:148153548-148378738 (-)
DBA/2J	MGP_DBA2J_G0028783	protein coding gene	Chr4:133707954-133897007 (-)
FVB/NJ	MGP_FVBNJ_G0028750	protein coding gene	Chr4:132655269-132850933 (-)
LP/J	MGP_LPJ_G0028882	protein coding gene	Chr4:139310582-139513228 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028776	protein coding gene	Chr4:152330011-152532584 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029434	protein coding gene	Chr4:137622993-137819556 (-)
PWK/PhJ	MGP_PWKPhJ_G0027821	protein coding gene	Chr4:130493085-130689721 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027647	protein coding gene	Chr4:133412659-133605949 (-)
WSB/EiJ	MGP_WSBEiJ_G0028179	protein coding gene	Chr4:137777130-137976593 (-)

Human Ortholog

EPHB2, EPH receptor B2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHB2, EPH receptor B2
Synonyms

BDPLT22, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
Links

HGNC:3393

NCBI Gene ID: 2048

neXtProt AC: NX_P29323

UniProt: P29323
Chr Location

1p36.12; chr1:22710838-22921500 (+) GRCh38

MGI Vertebrate Homology

Ephb2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EPHB2
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Ephb2

Diseases

1 with human EPHB2 associations

				Human Disease	Mouse Models
				blood platelet disease IDs blood platelet disease DOID:2218 MESH:D001791 NCI:C131634 UMLS_CUI:C0005818

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 5 alleles in 5 genetic backgrounds
30 phenotypes from multigenic genotypes
94 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

38
Targeted

8
Genomic Mutations

3 involving Ephb2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity.

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All GO Annotations

142
GO References

30

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1353
Tissues

388
cDNA Data

82
Literature Summary

124

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EPHB2

ZFIN ephb2a, ephb2b

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All Sequences

55
RefSeq

14
UniProt

2
CCDS

CCDS18809.1, CCDS71498.1

Ensembl

ENSMUSG00000028664 (Evidence)
NCBI Gene

13844

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028664	Ensembl Gene Model \| MGI Sequence Detail	188450	C57BL/6J	± kb
transcript	ENSMUST00000059287	Ensembl \| MGI Sequence Detail	4804	Not Applicable
polypeptide	ENSMUSP00000058135	Ensembl \| MGI Sequence Detail	987	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007130 ephrin type-B receptor 2

(term hierarchy)
PDB

1JPA, 1KGY, 1NUK, 1SHW, 2HEN, 3ETP, 7S7K
EC

2.7.10.1
InterPro Domains

IPR001090 Ephrin receptor ligand binding domain

IPR027936 Ephrin receptor, transmembrane domain

IPR016257 Ephrin receptor type-A /type-B

IPR050449 Ephrin receptor tyrosine kinases

IPR034238 Ephrin type-B receptor 2, ligand binding domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
GlyGen

P54763 4 sites, 2 N-linked glycans (2 sites)

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All nucleic 97

Genomic 2

cDNA 85

Primer pair 3

Other 7

Microarray probesets 5

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MGD-MRK-16396, MGD-MRK-35869, MGD-MRK-36579, MGD-MRK-39556, MGI:109557

Summaries

All 294

Developmental Gene Expression 124

Gene Ontology 30

Phenotypes 94
Earliest

J:31545 Ben-David Y, et al., A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991 Feb;10(2):317-25
Latest

J:346066 Rasool D, et al., PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS. EMBO Rep. 2024 Mar;25(3):1256-1281

TSS for Ephb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44052	Chr4:136563278-136563293 (-)	13 bp
Tssr44051	Chr4:136546978-136546995 (-)	16,312 bp
Tssr44050	Chr4:136546844-136546859 (-)	16,447 bp
Tssr44049	Chr4:136513101-136513102 (-)	50,197 bp
Tssr44048	Chr4:136465481-136465485 (-)	97,816 bp
Tssr44047	Chr4:136422926-136422939 (-)	140,366 bp
Tssr44046	Chr4:136415347-136415354 (-)	147,948 bp
Tssr44045	Chr4:136415319-136415330 (-)	147,974 bp
Tssr44044	Chr4:136415301-136415310 (-)	147,993 bp
Tssr44043	Chr4:136403448-136403451 (-)	159,849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24