Adprh MGI Mouse Gene Detail - MGI:1098234 - ADP-ribosylarginine hydrolase

Symbol

Adprh
Name

ADP-ribosylarginine hydrolase
Synonyms

Arh1

Feature Type

protein coding gene
IDs

MGI:1098234
NCBI Gene: 11544
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr16:38265761-38273051 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.86 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

258 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098234	protein coding gene	Chr16:38264392-38273065 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022815	protein coding gene	Chr16:36973891-36981170 (-)
A/J	MGP_AJ_G0022780	protein coding gene	Chr16:35137540-35144819 (-)
AKR/J	MGP_AKRJ_G0022752	protein coding gene	Chr16:36473762-36481041 (-)
BALB/cJ	MGP_BALBcJ_G0022781	protein coding gene	Chr16:35260199-35267478 (-)
C3H/HeJ	MGP_C3HHeJ_G0022545	protein coding gene	Chr16:36577017-36584296 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023228	protein coding gene	Chr16:37816013-37823303 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020743	protein coding gene	Chr16:35513857-35521293 (-)
CAST/EiJ	MGP_CASTEiJ_G0022071	protein coding gene	Chr16:36732646-36739925 (-)
CBA/J	MGP_CBAJ_G0022516	protein coding gene	Chr16:39473387-39480666 (-)
DBA/2J	MGP_DBA2J_G0022648	protein coding gene	Chr16:35022901-35030180 (-)
FVB/NJ	MGP_FVBNJ_G0022623	protein coding gene	Chr16:35053115-35060394 (-)
LP/J	MGP_LPJ_G0022716	protein coding gene	Chr16:36653299-36660578 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022642	protein coding gene	Chr16:38590531-38597810 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023243	protein coding gene	Chr16:36437214-36444493 (-)
PWK/PhJ	MGP_PWKPhJ_G0021811	protein coding gene	Chr16:35436650-35443924 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021642	protein coding gene	Chr16:36331557-36338517 (-)
WSB/EiJ	MGP_WSBEiJ_G0022115	protein coding gene	Chr16:36507288-36514569 (-)

Human Ortholog

ADPRH, ADP-ribosylarginine hydrolase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADPRH, ADP-ribosylarginine hydrolase
Synonyms

ARH1, hARH1
Links

HGNC:269

NCBI Gene ID: 141

neXtProt AC: NX_P54922

UniProt: P54922
Chr Location

3q13.33; chr3:119579268-119589945 (+) GRCh38

MGI Vertebrate Homology

Adprh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADPRH
Protein SuperFamily

ADP_ribslarg_hdr
Gene Tree

Adprh

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

3
Gene trapped

26
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

Mice homozygous for a null allele exhibit increased sensitivity to the effects of cholera toxin.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

124
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adprh

ZFIN adprh

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All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS28167.1

Ensembl

ENSMUSG00000002844 (Evidence)
NCBI Gene

11544

			Length	Strain/Species	Flank
genomic	11544	NCBI Gene Model \| MGI Sequence Detail	7291	C57BL/6J	± kb
transcript	NM_007414	RefSeq \| MGI Sequence Detail	1583	C57BL/6
polypeptide	P54923	UniProt \| EBI \| MGI Sequence Detail	362	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003788 ADP-ribosylhydrolase ARH1

(term hierarchy)
EC

3.2.2.19
InterPro Domains

IPR012108 ADP-ribosylarginine hydrolase

IPR005502 ADP-ribosylation/Crystallin J1

IPR036705 ADP-ribosylation/Crystallin J1 superfamily

IPR050792 ADP-ribosylglycohydrolase

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All nucleic 124

cDNA 124

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 13
Earliest

J:43393 Takada T, et al., Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase. J Biol Chem. 1993 Aug 25;268(24):17837-43
Latest

J:310399 Ishiwata-Endo H, et al., Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair. JCI Insight. 2018 Nov 15;3(22)

TSS for Adprh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141081	Chr16:38273045-38273066 (-)	-5 bp
Tssr141080	Chr16:38272974-38273037 (-)	45 bp
Tssr141079	Chr16:38268791-38268798 (-)	4,256 bp
Tssr141078	Chr16:38268032-38268043 (-)	5,013 bp
Tssr141077	Chr16:38267964-38267992 (-)	5,073 bp
Tssr141076	Chr16:38267934-38267962 (-)	5,103 bp
Tssr141075	Chr16:38267882-38267930 (-)	5,145 bp
Tssr141074	Chr16:38267808-38267852 (-)	5,221 bp
Tssr141073	Chr16:38266302-38266331 (-)	6,734 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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