Fabp2 MGI Mouse Gene Detail - MGI:95478 - fatty acid binding protein 2, intestinal

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Fabp2 Gene Detail

Symbol

Fabp2
Name

fatty acid binding protein 2, intestinal
Synonyms

Fabpi, Fabpi, I-FABP

Feature Type

protein coding gene
IDs

MGI:95478
NCBI Gene: 14079
Alliance

gene page
Transcription Start Sites

4 TSS
Candidate for QTL

3 QTL

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Sequence Map

Chr3:122688721-122693155 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 53.74 cM
Mapping Data

7 experiments

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SNPs within 2kb

222 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95478	protein coding gene	Chr3:122688721-122693155 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027842	protein coding gene	Chr3:125185655-125190087 (+)
A/J	MGP_AJ_G0027801	protein coding gene	Chr3:120996095-121000528 (+)
AKR/J	MGP_AKRJ_G0027766	protein coding gene	Chr3:124085966-124090400 (+)
BALB/cJ	MGP_BALBcJ_G0027813	protein coding gene	Chr3:120811482-120815915 (+)
C3H/HeJ	MGP_C3HHeJ_G0027543	protein coding gene	Chr3:124481434-124485867 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028258	protein coding gene	Chr3:129727535-129731969 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025597	protein coding gene	Chr3:116422196-116426622 (+)
CAST/EiJ	MGP_CASTEiJ_G0026999	protein coding gene	Chr3:123878426-123882861 (+)
CBA/J	MGP_CBAJ_G0027518	protein coding gene	Chr3:134109184-134113617 (+)
DBA/2J	MGP_DBA2J_G0027659	protein coding gene	Chr3:120123614-120128048 (+)
FVB/NJ	MGP_FVBNJ_G0027627	protein coding gene	Chr3:117739899-117744333 (+)
LP/J	MGP_LPJ_G0027769	protein coding gene	Chr3:126701744-126706176 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027657	protein coding gene	Chr3:141658066-141663048 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028314	protein coding gene	Chr3:123644582-123649016 (+)
PWK/PhJ	MGP_PWKPhJ_G0026725	protein coding gene	Chr3:119850836-119855322 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026548	protein coding gene	Chr3:121742691-121747105 (+)
WSB/EiJ	MGP_WSBEiJ_G0027079	protein coding gene	Chr3:124380371-124384804 (+)

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Human Ortholog

FABP2, fatty acid binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FABP2, fatty acid binding protein 2
Synonyms

FABPI, I-FABP
Links

HGNC:3556

NCBI Gene ID: 2169

neXtProt AC: NX_P12104

UniProt: P12104
Chr Location

4q26; chr4:119317250-119322138 (-) GRCh38

MGI Vertebrate Homology

Fabp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FABP2
Gene Tree

Fabp2

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Diseases

5 with human FABP2 associations

				Human Disease	Mouse Models
				alcoholic liver cirrhosis IDs alcoholic liver cirrhosis DOID:14018 ICD10CM:K70.3 ICD9CM_2006:571.2 ICD9CM:571.2 MESH:D008104 NCI:C34782 UMLS_CUI:C0023891
				carotid stenosis IDs carotid stenosis DOID:13001 MESH:D016893 NCI:C95804 UMLS_CUI:C0007282
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				end stage renal disease IDs end stage renal disease DOID:783
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Fabp2
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mutant mice exhibit increased body weight, hyperinsulinemia, increased leptin levels on a high fat diet and have elevated circulating levels of triglycerides. Female mutant mice exhibit a decreased body weight on a high fat diet compared to controls.

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All GO Annotations

21
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

773
Tissues

57
cDNA Data

65
Literature Summary

30

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FABP2

Xenbase fabp2

ZFIN fabp2

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS17813.1

Ensembl

ENSMUSG00000023057 (Evidence)
NCBI Gene

14079

Representative Sequences				Length	Strain/Species	Flank
	genomic	14079	NCBI Gene Model \| MGI Sequence Detail	4435	C57BL/6J	± kb
	transcript	NM_007980	RefSeq \| MGI Sequence Detail	977	Not Specified
	polypeptide	P55050	UniProt \| EBI \| MGI Sequence Detail	132	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007310 fatty acid-binding protein, intestinal

(term hierarchy)
InterPro Domains

IPR012674 Calycin

IPR000463 Cytosolic fatty-acid binding

IPR031272 Fatty acid-binding protein, intestinal

IPR031259 Intracellular lipid binding protein

IPR000566 Lipocalin/cytosolic fatty-acid binding domain

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All nucleic 74

Genomic 1

cDNA 67

Primer pair 5

Other 1

Microarray probesets 3

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MGD-MRK-9705

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Summaries

All 78

Developmental Gene Expression 30

Diseases 1

Gene Ontology 4

Phenotypes 14
Earliest

J:7317 Alpers DH, et al., Cloning of a cDNA encoding rat intestinal fatty acid binding protein. Proc Natl Acad Sci U S A. 1984 Jan;81(2):313-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fabp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31531	Chr3:122689018-122689033 (+)	305 bp
Tssr31532	Chr3:122690382-122690422 (+)	1,681 bp
Tssr31533	Chr3:122692986-122693032 (+)	4,288 bp
Tssr31534	Chr3:122693092-122693108 (+)	4,379 bp

Fabp2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bglq3	Chr3, 76.22 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 3, Hps3 (12.5 cM) showed differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Insq3 (2.6 cM) maps near this candidate gene.Candidate genes for diabesity QTLs Bglq3 (49 cM) and Wt10q2 (61 cM) are Fabp2 (55 cM) and Ampd2 (50.4 cM). Fabp2 shows differential expression between the restricted and unrestricted diets on the A/a background and Ampd2 shows differential expression between the restricted and unrestricted diets on the A/A background.
Insq3	Chr3, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 3, Hps3 (12.5 cM) showed differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Insq3 (2.6 cM) maps near this candidate gene.Candidate genes for diabesity QTLs Bglq3 (49 cM) and Wt10q2 (61 cM) are Fabp2 (55 cM) and Ampd2 (50.4 cM). Fabp2 shows differential expression between the restricted and unrestricted diets on the A/a background and Ampd2 shows differential expression between the restricted and unrestricted diets on the A/A background.
Wt10q2	Chr3, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 3, Hps3 (12.5 cM) showed differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Insq3 (2.6 cM) maps near this candidate gene.Candidate genes for diabesity QTLs Bglq3 (49 cM) and Wt10q2 (61 cM) are Fabp2 (55 cM) and Ampd2 (50.4 cM). Fabp2 shows differential expression between the restricted and unrestricted diets on the A/a background and Ampd2 shows differential expression between the restricted and unrestricted diets on the A/A background.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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