Tac2 MGI Mouse Gene Detail - MGI:98476

Symbol

Tac2
Name

tachykinin 2
Synonyms

neurokinin 2, neurokinin A, neurokinin alpha, neuromedin L, neuropeptide K, substance K

Feature Type

protein coding gene
IDs

MGI:98476
NCBI Gene: 21334
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:127560347-127567637 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 74.81 cM, cytoband D3
Mapping Data

1 experiment

SNPs within 2kb

300 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98476	protein coding gene	Chr10:127560347-127567637 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017832	protein coding gene	Chr10:131350842-131360279 (+)
A/J	MGP_AJ_G0017807	protein coding gene	Chr10:126097646-126104919 (+)
AKR/J	MGP_AKRJ_G0017770	protein coding gene	Chr10:129816436-129823721 (+)
BALB/cJ	MGP_BALBcJ_G0017771	protein coding gene	Chr10:126497657-126505091 (+)
C3H/HeJ	MGP_C3HHeJ_G0017595	protein coding gene	Chr10:129972819-129981211 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018226	protein coding gene	Chr10:135799932-135808696 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015906	protein coding gene	Chr10:120079088-120085991 (+)
CAST/EiJ	MGP_CASTEiJ_G0017155	protein coding gene	Chr10:130639410-130648557 (+)
CBA/J	MGP_CBAJ_G0017564	protein coding gene	Chr10:141283791-141292620 (+)
DBA/2J	MGP_DBA2J_G0017670	protein coding gene	Chr10:125169814-125178132 (+)
FVB/NJ	MGP_FVBNJ_G0017665	protein coding gene	Chr10:124113927-124124009 (+)
LP/J	MGP_LPJ_G0017744	protein coding gene	Chr10:131926523-131935113 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017693	protein coding gene	Chr10:143959634-143968253 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018266	protein coding gene	Chr10:129894905-129903536 (+)
PWK/PhJ	MGP_PWKPhJ_G0016940	protein coding gene	Chr10:125379090-125386428 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016732	protein coding gene	Chr10:128921833-128929156 (+)
WSB/EiJ	MGP_WSBEiJ_G0017216	protein coding gene	Chr10:130113773-130122584 (+)

Human Ortholog

TAC3, tachykinin precursor 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAC3, tachykinin precursor 3
Synonyms

HH10, LncZBTB39, NK3, NKB, NKNB, PRO1155, ZNEUROK1
Links

HGNC:11521

NCBI Gene ID: 6866

neXtProt AC: NX_Q9UHF0

UniProt: Q9UHF0
Chr Location

12q13.3; chr12:57010000-57028883 (-) GRCh38

MGI Vertebrate Homology

Tac2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TAC3
Protein SuperFamily

Neurokinin
Gene Tree

Tac2

Diseases

1 with human TAC3 associations

				Human Disease	Mouse Models
				hypogonadotropic hypogonadism 10 with or without anosmia IDs hypogonadotropic hypogonadism 10 with or without anosmia DOID:0090089 ICD10CM:E23.0 OMIM:614839

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 6 alleles in 6 genetic backgrounds
1 phenotype from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

5
Gene trapped

2
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit delayed female sexual maturation and fertility.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

78
cDNA Data

11
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tac3a, tac3b

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS24248.1

Ensembl

ENSMUSG00000025400 (Evidence)
NCBI Gene

21334

			Length	Strain/Species	Flank
genomic	21334	NCBI Gene Model \| MGI Sequence Detail	7291	C57BL/6J	± kb
transcript	NM_001199971	RefSeq \| MGI Sequence Detail	870	C57BL/6
polypeptide	P55099	UniProt \| EBI \| MGI Sequence Detail	116	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016004 tachykinin-3

(term hierarchy)
InterPro Domains

IPR003635 Neurokinin-B/Tachykinin-3

IPR013055 Tachykinin/Neurokinin-like, conserved site

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 3

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MGD-MRK-14703

Summaries

All 74

Developmental Gene Expression 13

Gene Ontology 6

Phenotypes 35
Earliest

J:15584 Kako K, et al., Cloning and Sequence Analysis of Mouse cDNAs Encoding Preprotachykinin-A and Preprotachykinin-B. Biomed Res. 1993 Aug;14(4):253-259
Latest

J:352544 Florido A, et al., Sex differences in neural projections of fear memory processing in mice and humans. Sci Adv. 2024 Jul 12;10(28):eadk3365

TSS for Tac2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96249	Chr10:127561241-127561256 (+)	902 bp
Tssr96250	Chr10:127561261-127561276 (+)	922 bp
Tssr96251	Chr10:127564445-127564449 (+)	4,100 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24