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Lrpap1 Gene Detail
Summary
  • Symbol
    Lrpap1
  • Name
    low density lipoprotein receptor-related protein associated protein 1
  • Synonyms
    RAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:96829
    NCBI Gene: 16976
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35248834-35263043 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.01 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    563 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96829
 protein coding gene Chr5:35248834-35263110 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029476
 protein coding gene Chr5:33352500-33366826 (-)
A/J MGP_AJ_G0029443
 protein coding gene Chr5:32270704-32284978 (-)
AKR/J MGP_AKRJ_G0029392
 protein coding gene Chr5:33503404-33517635 (-)
BALB/cJ MGP_BALBcJ_G0029453
 protein coding gene Chr5:32792354-32806557 (-)
C3H/HeJ MGP_C3HHeJ_G0029175
 protein coding gene Chr5:33529439-33543748 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029907
 protein coding gene Chr5:35253636-35270102 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027144
 protein coding gene Chr5:30030789-30044518 (-)
CAST/EiJ MGP_CASTEiJ_G0028584
 protein coding gene Chr5:32600648-32616310 (-)
CBA/J MGP_CBAJ_G0029143
 protein coding gene Chr5:36071807-36088083 (-)
DBA/2J MGP_DBA2J_G0029291
 protein coding gene Chr5:32418136-32432373 (-)
FVB/NJ MGP_FVBNJ_G0029250
 protein coding gene Chr5:31866364-31884144 (-)
LP/J MGP_LPJ_G0029376
 protein coding gene Chr5:33773554-33788654 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029280
 protein coding gene Chr5:36912151-36926381 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029940
 protein coding gene Chr5:33006466-33021819 (-)
PWK/PhJ MGP_PWKPhJ_G0028309
 protein coding gene Chr5:31557499-31590614 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028140
 protein coding gene Chr5:32431894-32471960 (-)
WSB/EiJ MGP_WSBEiJ_G0028665
 protein coding gene Chr5:33069787-33083939 (-)



Homology
more
  • Human Ortholog
    LRPAP1, LDL receptor related protein associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRPAP1, LDL receptor related protein associated protein 1
  • Synonyms
    A2MRAP, A2RAP, alpha-2-MRAP, HBP44, MRAP, MYP23, RAP
  • Links
    NCBI Gene ID: 4043
    neXtProt AC: NX_P30533
    UniProt: P30533

  • Chr Location
    4p16.3; chr4:3503612-3532446 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human LRPAP1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, subtle abnormalities are seen in behavior, brain function and thyroid function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    935
  • Tissues
    91
  • cDNA Data
    258
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16976 NCBI Gene Model | MGI Sequence Detail 14210 C57BL/6J ±  kb
    transcript NM_013587 RefSeq | MGI Sequence Detail 2925 ZRU/MplStud  
    polypeptide P55302 UniProt | EBI | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000009929 alpha-2-macroglobulin receptor-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR010483 Alpha-2-macroglobulin RAP, C-terminal
      IPR038001 Alpha-2-macroglobulin RAP, domain 2
      IPR037999 Alpha-2-macroglobulin RAP, domain 3
      IPR038003 Alpha-2-macroglobulin receptor-associated protein
      IPR009066 Alpha-2-macroglobulin receptor-associated protein, domain 1
      IPR036744 RAP domain superfamily
    • GlyGen
      P55302 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 265
      Genomic 3
      cDNA 259
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11887, MGI:2140781, MGI:2140964, MGI:2141085, MGI:2141295
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 10
      Phenotypes 40
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory