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Gabrr2 Gene Detail
Summary
  • Symbol
    Gabrr2
  • Name
    gamma-aminobutyric acid type A receptor subunit rho 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95626
    NCBI Gene: 14409
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33062999-33095865 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 14.64 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1197 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95626
 protein coding gene Chr4:33057715-33095865 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028118
 protein coding gene Chr4:30557968-30593051 (+)
A/J MGP_AJ_G0028076
 protein coding gene Chr4:29465499-29498764 (+)
AKR/J MGP_AKRJ_G0028039
 protein coding gene Chr4:30232353-30264973 (+)
BALB/cJ MGP_BALBcJ_G0028087
 protein coding gene Chr4:29727988-29760809 (+)
C3H/HeJ MGP_C3HHeJ_G0027816
 protein coding gene Chr4:30520484-30557159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028529
 protein coding gene Chr4:31753394-31794034 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025870
 protein coding gene Chr4:27530694-27564458 (+)
CAST/EiJ MGP_CASTEiJ_G0027271
 protein coding gene Chr4:30299644-30340586 (+)
CBA/J MGP_CBAJ_G0027788
 protein coding gene Chr4:32789019-32824271 (+)
DBA/2J MGP_DBA2J_G0027932
 protein coding gene Chr4:29467938-29502530 (+)
FVB/NJ MGP_FVBNJ_G0027898
 protein coding gene Chr4:28894847-28931545 (+)
LP/J MGP_LPJ_G0028040
 protein coding gene Chr4:30648429-30684247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027931
 protein coding gene Chr4:35351276-35393094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028588
 protein coding gene Chr4:30242642-30281380 (+)
PWK/PhJ MGP_PWKPhJ_G0026990
 protein coding gene Chr4:29472545-29508518 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026819
 protein coding gene Chr4:30129838-30168920 (+)
WSB/EiJ MGP_WSBEiJ_G0027347
 protein coding gene Chr4:30239685-30277824 (+)



Homology
more
  • Human Ortholog
    GABRR2, gamma-aminobutyric acid type A receptor subunit rho2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRR2, gamma-aminobutyric acid type A receptor subunit rho2
  • Links
    NCBI Gene ID: 2570
    neXtProt AC: NX_P28476
    UniProt: P28476

  • Chr Location
    6q15; chr6:89254464-89315299 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GABRR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    43
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023267 Ensembl Gene Model | MGI Sequence Detail 32867 C57BL/6J ±  kb
    transcript ENSMUST00000024035 Ensembl | MGI Sequence Detail 1820 Not Applicable  
    polypeptide ENSMUSP00000024035 Ensembl | MGI Sequence Detail 490 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007783 gamma-aminobutyric acid receptor subunit rho-2
      (term hierarchy)
    • InterPro Domains
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR008057 Gamma-aminobutyric-acid A receptor, Rho
      IPR008059 Gamma-aminobutyric-acid A receptor, Rho2
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      P56476 2 sites
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9945
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:2295 Cutting GR, et al., Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 1992 Apr;12(4):801-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory