Ackr3 MGI Mouse Gene Detail - MGI:109562 - atypical chemokine receptor 3

Symbol

Ackr3
Name

atypical chemokine receptor 3
Synonyms

Cmkor1, Cxcr7, Rdc1

Feature Type

protein coding gene
IDs

MGI:109562
NCBI Gene: 12778
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:90131702-90143446 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 45.28 cM
Mapping Data

4 experiments

SNPs within 2kb

349 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109562	protein coding gene	Chr1:90131702-90144473 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016294	protein coding gene	Chr1:91680073-91692832 (+)
A/J	MGP_AJ_G0016275	protein coding gene	Chr1:88404926-88417700 (+)
AKR/J	MGP_AKRJ_G0016236	protein coding gene	Chr1:91015901-91028661 (+)
BALB/cJ	MGP_BALBcJ_G0016231	protein coding gene	Chr1:88564871-88577645 (+)
C3H/HeJ	MGP_C3HHeJ_G0016060	protein coding gene	Chr1:91225138-91237909 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016690	protein coding gene	Chr1:95233942-95246709 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014408	protein coding gene	Chr1:82686821-82699439 (+)
CAST/EiJ	MGP_CASTEiJ_G0015645	protein coding gene	Chr1:90553735-90565412 (+)
CBA/J	MGP_CBAJ_G0016036	protein coding gene	Chr1:98279630-98292398 (+)
DBA/2J	MGP_DBA2J_G0016139	protein coding gene	Chr1:87633616-87646390 (+)
FVB/NJ	MGP_FVBNJ_G0016138	protein coding gene	Chr1:86648553-86661304 (+)
LP/J	MGP_LPJ_G0016210	protein coding gene	Chr1:92822193-92834954 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016163	protein coding gene	Chr1:101548815-101561586 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016730	protein coding gene	Chr1:91040346-91053101 (+)
PWK/PhJ	MGP_PWKPhJ_G0015429	protein coding gene	Chr1:87025257-87038008 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015212	protein coding gene	Chr1:89953691-89965307 (+)
WSB/EiJ	MGP_WSBEiJ_G0015703	protein coding gene	Chr1:90774784-90787533 (+)

Human Ortholog

ACKR3, atypical chemokine receptor 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACKR3, atypical chemokine receptor 3
Synonyms

CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1
Links

HGNC:23692

NCBI Gene ID: 57007

neXtProt AC: NX_P25106

UniProt: P25106
Chr Location

2q37.3; chr2:236537122-236582354 (+) GRCh38

MGI Vertebrate Homology

Ackr3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACKR3
Gene Tree

Ackr3

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Phenotype Summary

58 phenotypes from 9 alleles in 9 genetic backgrounds
3 images
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Radiation induced

1
Targeted

21
Genomic Mutations

2 involving Ackr3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most homozygous null mutations result in perinatal lethality with cardiac defects including semilunar valve defects.

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All GO Annotations

45
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1097
Tissues

138
cDNA Data

11
Literature Summary

50

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ackr3

ZFIN ackr3a, ackr3b

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All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS15152.1

Ensembl

ENSMUSG00000044337 (Evidence)
NCBI Gene

12778

			Length	Strain/Species	Flank
genomic	12778	NCBI Gene Model \| MGI Sequence Detail	11745	C57BL/6J	± kb
transcript	NM_001271607	RefSeq \| MGI Sequence Detail	2321	ZRU/MplStud
polypeptide	P56485	UniProt \| EBI \| MGI Sequence Detail	362	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001211 atypical chemokine receptor 3

(term hierarchy)
InterPro Domains

IPR001416 Atypical chemokine receptor 3

IPR017452 GPCR, rhodopsin-like, 7TM

IPR047143 G-protein coupled estrogen receptor 1-like

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P56485 3 sites, 1 N-linked glycan (1 site)

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All nucleic 17

cDNA 12

Primer pair 1

Other 4

Microarray probesets 3

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MGD-MRK-39561, MGI:2138598

Summaries

All 144

Developmental Gene Expression 50

Gene Ontology 10

Phenotypes 57
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354184 Pineiro-Sabaris R, et al., Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve. Dis Model Mech. 2024 Sep 1;17(9)

TSS for Ackr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8015	Chr1:90131717-90131734 (+)	24 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24