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Cyp2c39 Gene Detail
Summary
  • Symbol
    Cyp2c39
  • Name
    cytochrome P450, family 2, subfamily c, polypeptide 39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306818
    NCBI Gene: 13098
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:39499306-39556973 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 34.15 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1533 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306818
 protein coding gene Chr19:39335790-39558012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025102
 protein coding gene Chr19:38630184-38680584 (+)
A/J MGP_AJ_G0025078
 protein coding gene Chr19:36710666-36761346 (+)
AKR/J MGP_AKRJ_G0025046
 protein coding gene Chr19:37937339-37999614 (+)
BALB/cJ MGP_BALBcJ_G0025076
 protein coding gene Chr19:36854724-36911567 (+)
C3H/HeJ MGP_C3HHeJ_G0024835
 protein coding gene Chr19:38040111-38109286 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025517
 protein coding gene Chr19:39660264-39719547 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0024301
 protein coding gene Chr19:37844879-37909115 (+)
CBA/J MGP_CBAJ_G0024812
 protein coding gene Chr19:41576560-41659251 (+)
DBA/2J MGP_DBA2J_G0024944
 protein coding gene Chr19:36570245-36634780 (+)
FVB/NJ MGP_FVBNJ_G0024905
 protein coding gene Chr19:36399113-36449055 (+)
LP/J MGP_LPJ_G0025030
 protein coding gene Chr19:38657827-38732332 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024936
 protein coding gene Chr19:41291302-41346267 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025575
 protein coding gene Chr19:38052133-38109783 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0023853
 protein coding gene Chr19:36888724-36953898 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CYP2C18, cytochrome P450 family 2 subfamily C member 18
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2C18, cytochrome P450 family 2 subfamily C member 18
  • Synonyms
    CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
  • Links
    NCBI Gene ID: 1562
    neXtProt AC: NX_P33260
    UniProt: P33260

  • Chr Location
    10q23.33; chr10:94683729-94736190 (+)  GRCh38
  • Human Ortholog
    CYP2C19, cytochrome P450 family 2 subfamily C member 19
  • Synonyms
    CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
  • Links
    NCBI Gene ID: 1557
    neXtProt AC: NX_P33261
    UniProt: P33261

  • Chr Location
    10q23.33; chr10:94762681-94855547 (+)  GRCh38
  • Human Ortholog
    CYP2C8, cytochrome P450 family 2 subfamily C member 8
  • Synonyms
    CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
  • Links
    NCBI Gene ID: 1558
    neXtProt AC: NX_P10632
    UniProt: P10632

  • Chr Location
    10q23.33; chr10:95036772-95069497 (-)  GRCh38
  • Human Ortholog
    CYP2C9, cytochrome P450 family 2 subfamily C member 9
  • Synonyms
    CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
  • Links
    NCBI Gene ID: 1559
    neXtProt AC: NX_P11712
    UniProt: P11712

  • Chr Location
    10q23.33; chr10:94938658-94990091 (+)  GRCh38
Human Diseases
more
  • Diseases
    21 with human CYP2C19,CYP2C8,CYP2C9 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
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IDs
IDs
IDs
IDs
IDs
IDs
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IDs
IDs
IDs
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IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    5
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025003 Ensembl Gene Model | MGI Sequence Detail 57668 C57BL/6J ±  kb
transcript ENSMUST00000025968 Ensembl | MGI Sequence Detail 1817 Not Applicable  
polypeptide ENSMUSP00000025968 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:49570 Luo G, et al., Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. Arch Biochem Biophys. 1998 Sep 1;357(1):45-57
  • Latest
    J:341617 Zhang J, et al., CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. FASEB J. 2023 Jul;37(7):e23009
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory